Alteration of GTP-binding proteins in ovarian tumors (Review)
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- Published online on: March 1, 1996 https://doi.org/10.3892/or.3.2.241
- Pages: 241-243
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Abstract
GTP-binding proteins (G proteins) couple cell surface receptors to generation of a variety of intracellular second messengers. The mutant G protein products may be responsible for trapping the protein in its active and subsequently the abnormal growth of malignant cells and dysfunction. We present recent examples of G protein gene mutations in ovarian tumors and illustrate how such defects might lead to abnormal tumor proliferation.
