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Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase

  • Authors:
    • D Martin
    • R Stolfi
    • L Nord
    • J Colofiore

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  • Published online on: March 1, 1996     https://doi.org/10.3892/or.3.2.317
  • Pages: 317-322
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

An inhibitor of poly (ADP-ribose) polymerase, 1,5-dihydroxyisoquinoline (DHIQ), evaluated in vivo against a murine advanced breast cancer, significantly improved by 20% the PR rate of tumor-regressing chemotherapy. A detailed sequential biochemical cascade is proposed for chemotherapy-induced apoptosis, and the rationale for the utilization of the inhibitor is explained.

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March 1996
Volume 3 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Martin D, Stolfi R, Nord L and Colofiore J: Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase. Oncol Rep 3: 317-322, 1996
APA
Martin, D., Stolfi, R., Nord, L., & Colofiore, J. (1996). Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase. Oncology Reports, 3, 317-322. https://doi.org/10.3892/or.3.2.317
MLA
Martin, D., Stolfi, R., Nord, L., Colofiore, J."Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase". Oncology Reports 3.2 (1996): 317-322.
Chicago
Martin, D., Stolfi, R., Nord, L., Colofiore, J."Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase". Oncology Reports 3, no. 2 (1996): 317-322. https://doi.org/10.3892/or.3.2.317