A phase I evaluation of chronotropic delivery of floxuridine by hepatic arterial infusion in patients with metastatic colorectal cancer

  • Authors:
    • D Jones
    • J Chase
    • M Roh
    • D Hohn
    • S Curley
    • R Smith
    • A Hoque
    • Y Patt
  • View Affiliations

  • Published online on: March 1, 1996     https://doi.org/10.3892/or.3.2.391
  • Pages: 391-395
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Abstract

Hepatic arterial infusion (HAI) of floxuridine is often used for metastatic colorectal cancer, though this is associated with dose-limiting hepatobiliary toxicity. A phase I trial was initiated to determine if circadian-patterned HAI floxuridine would reduce toxicity. Twenty-one patients were enrolled, and they received a continuous 14-day HAI of floxuridine, with 90-95% of the drug delivered over the same six-hour period daily. The therapy was tolerable, but there was no reduction in hepatobiliary toxicity. The response rate of 33% (1 complete and 6 partial responses) was similar to that of regimens that do not utilize circadian timing. HAI floxuridine chronotherapy for metastatic colorectal cancer cannot be recommended.

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March 1996
Volume 3 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jones D, Chase J, Roh M, Hohn D, Curley S, Smith R, Hoque A and Patt Y: A phase I evaluation of chronotropic delivery of floxuridine by hepatic arterial infusion in patients with metastatic colorectal cancer. Oncol Rep 3: 391-395, 1996
APA
Jones, D., Chase, J., Roh, M., Hohn, D., Curley, S., Smith, R. ... Patt, Y. (1996). A phase I evaluation of chronotropic delivery of floxuridine by hepatic arterial infusion in patients with metastatic colorectal cancer. Oncology Reports, 3, 391-395. https://doi.org/10.3892/or.3.2.391
MLA
Jones, D., Chase, J., Roh, M., Hohn, D., Curley, S., Smith, R., Hoque, A., Patt, Y."A phase I evaluation of chronotropic delivery of floxuridine by hepatic arterial infusion in patients with metastatic colorectal cancer". Oncology Reports 3.2 (1996): 391-395.
Chicago
Jones, D., Chase, J., Roh, M., Hohn, D., Curley, S., Smith, R., Hoque, A., Patt, Y."A phase I evaluation of chronotropic delivery of floxuridine by hepatic arterial infusion in patients with metastatic colorectal cancer". Oncology Reports 3, no. 2 (1996): 391-395. https://doi.org/10.3892/or.3.2.391