Detection of hepatitis B virus genome in hepatocellular carcinoma from both hepatitis B surface antigen- and antibody to hepatitis C virus-negative patients

  • Authors:
    • H Kamito
    • K Nakata
    • K Hamasaki
    • M Daikoku
    • F Mawatari
    • T Ueki
    • Y Hayashida
    • K Nakao
    • Y Kato
    • S Nagataki
  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/or.3.4.619
  • Pages: 619-623
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Abstract

Twenty-two patients who tested seronegative for both hepatitis B virus (HBV) and hepatitis C virus (HCV) markers and undefined pathogenesis of hepatocellular carcinoma (HCC) were studied using polymerase chain reaction (PCR). Among these patients, 5 (23%) were positive for HBV-DNA in serum by PCR, but no patient was positive for HCV-RNA by reverse transcription PCR. Liver tissue specimens were available for analyzing HBV genome by PCR in 17 patients, and HBV sequences were detected in 10 (59%) patients. These results indicate that HBV is commonly implicated in serologically undefined pathogenesis of HCC in Japan.

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July 1996
Volume 3 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kamito H, Nakata K, Hamasaki K, Daikoku M, Mawatari F, Ueki T, Hayashida Y, Nakao K, Kato Y, Nagataki S, Nagataki S, et al: Detection of hepatitis B virus genome in hepatocellular carcinoma from both hepatitis B surface antigen- and antibody to hepatitis C virus-negative patients. Oncol Rep 3: 619-623, 1996.
APA
Kamito, H., Nakata, K., Hamasaki, K., Daikoku, M., Mawatari, F., Ueki, T. ... Nagataki, S. (1996). Detection of hepatitis B virus genome in hepatocellular carcinoma from both hepatitis B surface antigen- and antibody to hepatitis C virus-negative patients. Oncology Reports, 3, 619-623. https://doi.org/10.3892/or.3.4.619
MLA
Kamito, H., Nakata, K., Hamasaki, K., Daikoku, M., Mawatari, F., Ueki, T., Hayashida, Y., Nakao, K., Kato, Y., Nagataki, S."Detection of hepatitis B virus genome in hepatocellular carcinoma from both hepatitis B surface antigen- and antibody to hepatitis C virus-negative patients". Oncology Reports 3.4 (1996): 619-623.
Chicago
Kamito, H., Nakata, K., Hamasaki, K., Daikoku, M., Mawatari, F., Ueki, T., Hayashida, Y., Nakao, K., Kato, Y., Nagataki, S."Detection of hepatitis B virus genome in hepatocellular carcinoma from both hepatitis B surface antigen- and antibody to hepatitis C virus-negative patients". Oncology Reports 3, no. 4 (1996): 619-623. https://doi.org/10.3892/or.3.4.619