Immunocytochemical analysis of MDM2 protein expression and its relevance to tumor angiogenesis in primary breast cancer

  • Authors:
    • K Inada
    • M Toi
    • Y Yamamoto
    • A Suzuki
    • T Kurisaki
    • H Suzuki
    • T Tominaga
  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/or.3.4.667
  • Pages: 667-671
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Abstract

MDM2 once-protein is known to be involved in the inactivation of p53 and RE functions. We have investigated the expression of MDM2 protein in breast cancer by immunocytochemical analysis. Out of 103 primary tumors 39 (38%) showed positive nuclear staining of MDM2, although its gene amplification was infrequent. There was no correlation between MDM2 expression and various clinicopathological factors. However, MDM2 expression was significantly associated with expression of angiogenesis factors including vascular endothelial growth factor and platelet-derived endothelial cell growth factor. Anti-endothelial immunostaining demonstrated a correlation between MDM2 expression and the increment of intratumoral microvessel density. It is suggested that altered MDM2 protein expression might be involved in the promotion of angiogenesis in human breast cancer.

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July 1996
Volume 3 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Inada K, Toi M, Yamamoto Y, Suzuki A, Kurisaki T, Suzuki H and Tominaga T: Immunocytochemical analysis of MDM2 protein expression and its relevance to tumor angiogenesis in primary breast cancer. Oncol Rep 3: 667-671, 1996
APA
Inada, K., Toi, M., Yamamoto, Y., Suzuki, A., Kurisaki, T., Suzuki, H., & Tominaga, T. (1996). Immunocytochemical analysis of MDM2 protein expression and its relevance to tumor angiogenesis in primary breast cancer. Oncology Reports, 3, 667-671. https://doi.org/10.3892/or.3.4.667
MLA
Inada, K., Toi, M., Yamamoto, Y., Suzuki, A., Kurisaki, T., Suzuki, H., Tominaga, T."Immunocytochemical analysis of MDM2 protein expression and its relevance to tumor angiogenesis in primary breast cancer". Oncology Reports 3.4 (1996): 667-671.
Chicago
Inada, K., Toi, M., Yamamoto, Y., Suzuki, A., Kurisaki, T., Suzuki, H., Tominaga, T."Immunocytochemical analysis of MDM2 protein expression and its relevance to tumor angiogenesis in primary breast cancer". Oncology Reports 3, no. 4 (1996): 667-671. https://doi.org/10.3892/or.3.4.667