Maintenance therapy with recombinant interferon alpha-2B (alpha IFN) in prognostically unfavourable aggressive non-Hodgkin's lymphomas (NHL)

  • Authors:
    • G Palmieri
    • A Morabito
    • A Rea
    • R Lauria
    • V Montesarchio
    • E Biondi
    • M Caraglia
    • P Tagliaferri
    • A Bianco
  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/or.3.4.733
  • Pages: 733-735
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Fifteen patients from a series of 37 consecutive patients with aggressive NHL who achieved a complete remission (CR) with first line chemotherapy were defined at high or high-intermediate risk of relapse according to International Prognostic Risk Index and were treated with alpha IFN as maintenance therapy for two years. After a median follow-up of 62 months only 3/15 patients (20%) relapsed and 2/15 (13.3%) died in the alpha IFN treated group, favourably comparing with the expected relapse and death rate in that setting; on the other hand 40.9% of 'low risk' patients from the same series, who did not receive alpha IFN, had relapsed. alpha IFN maintenance therapy appears to result in prolonged response duration and survival in patients with aggressive and prognostically unfavourable NHL.

Related Articles

Journal Cover

July 1996
Volume 3 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Palmieri G, Morabito A, Rea A, Lauria R, Montesarchio V, Biondi E, Caraglia M, Tagliaferri P and Bianco A: Maintenance therapy with recombinant interferon alpha-2B (alpha IFN) in prognostically unfavourable aggressive non-Hodgkin's lymphomas (NHL). Oncol Rep 3: 733-735, 1996.
APA
Palmieri, G., Morabito, A., Rea, A., Lauria, R., Montesarchio, V., Biondi, E. ... Bianco, A. (1996). Maintenance therapy with recombinant interferon alpha-2B (alpha IFN) in prognostically unfavourable aggressive non-Hodgkin's lymphomas (NHL). Oncology Reports, 3, 733-735. https://doi.org/10.3892/or.3.4.733
MLA
Palmieri, G., Morabito, A., Rea, A., Lauria, R., Montesarchio, V., Biondi, E., Caraglia, M., Tagliaferri, P., Bianco, A."Maintenance therapy with recombinant interferon alpha-2B (alpha IFN) in prognostically unfavourable aggressive non-Hodgkin's lymphomas (NHL)". Oncology Reports 3.4 (1996): 733-735.
Chicago
Palmieri, G., Morabito, A., Rea, A., Lauria, R., Montesarchio, V., Biondi, E., Caraglia, M., Tagliaferri, P., Bianco, A."Maintenance therapy with recombinant interferon alpha-2B (alpha IFN) in prognostically unfavourable aggressive non-Hodgkin's lymphomas (NHL)". Oncology Reports 3, no. 4 (1996): 733-735. https://doi.org/10.3892/or.3.4.733