Feasibility of intra-arterial chemotherapy followed by chemoembolization, every 28 days, in unresectable hepatocellular carcinoma

  • Authors:
    • M Colleoni
    • G Liessi
    • G Mastrapasqua
    • P Nelli
    • G Vicario
    • G Sgarbossa
    • F Pancheri
    • P Manente
  • View Affiliations

  • Published online on: September 1, 1996     https://doi.org/10.3892/or.3.5.879
  • Pages: 879-882
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Abstract

Encouraging response rates and survival have been reported with intra-arterial (i.a.) chemotherapy and chemoembolization, but limited data are available on the association of the two treatment modalities. We therefore started a feasibility study of i.a. chemotherapy plus chemoembolization, performed every 28 days for 3 cycles, according to the following schedule: L-leucovorin (100 mg/m(2) i.v.), fluorouracil (800 mg/m(2) i.a.), and carboplatin (250 mg/m(2) i.a.). Chemoembolization with mitoxantrone (10 mg/m(2)) plus ethiodized oil was performed immediately after this treatment, followed by gelatin powder. Fourteen patients entered the study and were evaluable for side effects. Main patient characteristics were: males 13, females 1; median age 65 yr (range 45-75); stage TNM II-III 10, IVA 4; Childs' A 8, Childs' B 6; elevated baseline alpha-fetoprotein, 11; cirrhosis 14. No drug-related deaths have been observed. Ten patients were able to complete the program. The reasons for discontinuing treatment were worsening of liver functions in 3 cases and grade IV neutropenia in 1 patient. Eight patients had grade I-II pain and 10 patients had grade I-II fever. In conclusion the study demonstrated that chemoembolization plus i.a. chemotherapy is feasible in patients with hepatocellular carcinoma in cirrhosis and deserves further investigation.

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September 1996
Volume 3 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Colleoni M, Liessi G, Mastrapasqua G, Nelli P, Vicario G, Sgarbossa G, Pancheri F and Manente P: Feasibility of intra-arterial chemotherapy followed by chemoembolization, every 28 days, in unresectable hepatocellular carcinoma. Oncol Rep 3: 879-882, 1996
APA
Colleoni, M., Liessi, G., Mastrapasqua, G., Nelli, P., Vicario, G., Sgarbossa, G. ... Manente, P. (1996). Feasibility of intra-arterial chemotherapy followed by chemoembolization, every 28 days, in unresectable hepatocellular carcinoma. Oncology Reports, 3, 879-882. https://doi.org/10.3892/or.3.5.879
MLA
Colleoni, M., Liessi, G., Mastrapasqua, G., Nelli, P., Vicario, G., Sgarbossa, G., Pancheri, F., Manente, P."Feasibility of intra-arterial chemotherapy followed by chemoembolization, every 28 days, in unresectable hepatocellular carcinoma". Oncology Reports 3.5 (1996): 879-882.
Chicago
Colleoni, M., Liessi, G., Mastrapasqua, G., Nelli, P., Vicario, G., Sgarbossa, G., Pancheri, F., Manente, P."Feasibility of intra-arterial chemotherapy followed by chemoembolization, every 28 days, in unresectable hepatocellular carcinoma". Oncology Reports 3, no. 5 (1996): 879-882. https://doi.org/10.3892/or.3.5.879