The present study is an extension of the latest report from our laboratory, and attempts to investigate the etiological relevancy of the aging of the steroid generating system to the genesis of cervical cancer. The urinary steroid deviation profile of a cervical cancer patient has been known to commit distinct metamorphosis from young age through middle age to old age, and our access to the problem was designed to answer the question whether or not an ex-cervical cancer patient may develop a new primary malignant growth at an advanced age. In the practice of this study, we employed a regression analysis technique for the analysis of the urinary steroid deviation data of cervical cancer on the one hand, and applied the chi square test to the epidemiological data of the double cancer population on the other hand. Results obtained are as follows: i) The steroid deviation profile that was specific to cervical cancer patients chronologically coincided in its emergence with the quasi-exponential growth phase of cancer risk (before age 40); ii) After entry into the stagnation phase of cancer risk, a new change of urinary steroid excretions was progressing with age to the point that the steroid deviation profile of cervical cancer of old age (60 years) assumed an appearance that showed a remarkable resemblance with that of old-age breast cancer; iii) In accordance with the observed changes of the steroid deviation profile of cervical cancer, the breast cancer incidence of an ex-cervical cancer patient was significantly higher than the cervical cancer incidence of an ex-breast cancer patient, and the predominance of the former over the latter was found to be one of the most striking contrasts, as compared in a number of examples of 2 reciprocal cancer pairs of the double cancer population. The observed relationship between the hormonal and epidemiological findings of cancer patients is discussed from the view point of the steroid carcinogenesis hypothesis of human neoplasia.

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