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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1996 Volume 3 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1996 Volume 3 Issue 6

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Article

Differential synthesis and binding of hyaluronan by human breast cancer cell lines

  • Authors:
    • P Heldin
    • M delaTorre
    • D Ytterberg
    • J Bergh

  • View Affiliations / Copyright

    Affiliations: DANDERYD HOSP,DEPT PATHOL,S-18288 DANDERYD,SWEDEN. UNIV UPPSALA HOSP,DEPT ONCOL,S-75185 UPPSALA,SWEDEN.
  • Pages: 1011-1016
    |
    Published online on: November 1, 1996
       https://doi.org/10.3892/or.3.6.1011
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Abstract

In the present study we investigated a panel of human breast cancer cell lines which were sensitive or resistant to the cytotoxic drug doxorubicin, for their abilities to synthesize and bind hyaluronan. We found that MDA-231 and HS-578T cells which express very low amounts of estrogen and progesterone receptors, both synthesized hyaluronan and expressed hyaluronan binding sites on the cell surface as did their doxorubicin-adapted counterparts MDA-231 Dox and HS-578T Dox. The binding was highly specific with a K-d of 0.48x10(-9) M. Most of the hyaluronan binding activity was blocked by mAbs against Hermes-l antigen indicating that the adhesion molecule CD44 is responsible for hyaluronan binding. Only 0.5% of the total amount of labeled hyaluronan added to the cultures was degraded during a period of 16 h. The hormone positive receptor cell lines, MCF-5, Zr-5-1 and Zr-5-1 Dox synthesized only minute amounts of hyaluronan and did not bind hyaluronan or express CD44 receptors. Expression of CD44-related hyaluronan receptors and synthesized hyaluronan may endow hormone receptor negative cells with a highly hydrated environment that facilitates cell motility and invasiveness. The lack of CD44 and thereby the lack of ability to bind hyaluronan in the extracellular matrix may contribute to the non-invasive behavior of hormone positive cell lines.

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Copy and paste a formatted citation
Spandidos Publications style
Heldin P, delaTorre M, Ytterberg D and Bergh J: Differential synthesis and binding of hyaluronan by human breast cancer cell lines. Oncol Rep 3: 1011-1016, 1996.
APA
Heldin, P., delaTorre, M., Ytterberg, D., & Bergh, J. (1996). Differential synthesis and binding of hyaluronan by human breast cancer cell lines. Oncology Reports, 3, 1011-1016. https://doi.org/10.3892/or.3.6.1011
MLA
Heldin, P., delaTorre, M., Ytterberg, D., Bergh, J."Differential synthesis and binding of hyaluronan by human breast cancer cell lines". Oncology Reports 3.6 (1996): 1011-1016.
Chicago
Heldin, P., delaTorre, M., Ytterberg, D., Bergh, J."Differential synthesis and binding of hyaluronan by human breast cancer cell lines". Oncology Reports 3, no. 6 (1996): 1011-1016. https://doi.org/10.3892/or.3.6.1011
Copy and paste a formatted citation
x
Spandidos Publications style
Heldin P, delaTorre M, Ytterberg D and Bergh J: Differential synthesis and binding of hyaluronan by human breast cancer cell lines. Oncol Rep 3: 1011-1016, 1996.
APA
Heldin, P., delaTorre, M., Ytterberg, D., & Bergh, J. (1996). Differential synthesis and binding of hyaluronan by human breast cancer cell lines. Oncology Reports, 3, 1011-1016. https://doi.org/10.3892/or.3.6.1011
MLA
Heldin, P., delaTorre, M., Ytterberg, D., Bergh, J."Differential synthesis and binding of hyaluronan by human breast cancer cell lines". Oncology Reports 3.6 (1996): 1011-1016.
Chicago
Heldin, P., delaTorre, M., Ytterberg, D., Bergh, J."Differential synthesis and binding of hyaluronan by human breast cancer cell lines". Oncology Reports 3, no. 6 (1996): 1011-1016. https://doi.org/10.3892/or.3.6.1011
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