Local hyperthermia and radiation therapy in the treatment of superficially located lymphomas and recurrent Hodgkin's disease

Donato,V; Zurlo,A; Banelli,E; Santarelli,M; Anselmo,P; Martelli,M; Enrici,R; Biagini,C

doi:10.3892/or.3.6.1043

November 1996 Volume 3 Issue 6

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November 1996 Volume 3 Issue 6

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Article

Local hyperthermia and radiation therapy in the treatment of superficially located lymphomas and recurrent Hodgkin's disease

Authors:
- V Donato
- A Zurlo
- E Banelli
- M Santarelli
- P Anselmo
- M Martelli
- R Enrici
- C Biagini
View Affiliations / Copyright

Affiliations: UNIV ROMA LA SAPIENZA,DEPT HEMATOL,I-00136 ROME,ITALY. UNIV AQUILA,INST RADIOL,I-67100 LAQUILA,ITALY. UNIV ROMA TOR VERGATA,DEPT RADIOTHERAPY,ROME,ITALY.
Pages: 1043-1047
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Published online on: November 1, 1996

https://doi.org/10.3892/or.3.6.1043
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Abstract

The combination of radiation therapy CRT) and hyperthermia (HT) has proved to be an effective treatment of a wide variety of superficially located recurrences of different tumors, particularly those arising in previously irradiated areas. Some studies have been reported with the use of this combined approach in the management of cutaneous lymphomas or recurrent previously irradiated sites of Hodgkin's disease (HD). We report a small series of five patients with six located sites of recurrent HD, and four patients with six superficially located sites of non Hodgkin's lymphomas (NHL), all of them being treated with combined HT and RT at our institution. Local control was obtained in each of combined treatment fields, and all patients are alive after a median follow-up of 24 months. All the patients tolerated the HT treatments well, and in all cases average intratumoral temperatures were >42 degrees C, with 8 out of 12 sites achieving the goal of average temperatures >42.5 degrees C. Two patients, one with recurrent HD and one with NHL, are free of disease after 20 and 21 months from the end of combined therapy. Our results thus seem to confirm previous experiences, suggesting a role of HT/RT not only for palliative purposes in cutaneous lymphomas, but also in the management of selected, heavily pretreated patients with superficially located recurrences of HD.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Local hyperthermia and radiation therapy in the treatment of superficially located lymphomas and recurrent Hodgkin's disease

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Abstract

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