Inhibition of fibrinolysis by a synthetic urokinase inhibitor enhances lung colonization of metastatic murine mammary tumor cells

  • Authors:
    • D Alonso
    • G Bertolesi
    • E Farias
    • D Gomez
    • E Joffe
  • View Affiliations

  • Published online on: November 1, 1996     https://doi.org/10.3892/or.3.6.1055
  • Pages: 1055-1058
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Abstract

We have investigated the role of coagulation and fibrinolysis during the metastatic lung colonization of F3II mouse mammary carcinoma cells. The selective synthetic urokinase inhibitor B623 significantly enhanced lung colonization and blocked the antimetastatic effect of heparin when administered i.p. during the first stages of metastasis formation. In B623-treated mice the overall activity of the fibrinolytic system was reduced and circulating urokinase was specifically inhibited by this agent. In vitro studies demonstrated that B623 induces the aggregation of F3II cells in the presence of mouse plasma and facilitates the entrapment of tumor cells in a fibrin gel matrix. Our data suggest that imbalances of fibrin deposition and removal may dramatically influence metastatic lung colonization.

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November 1996
Volume 3 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Alonso D, Bertolesi G, Farias E, Gomez D and Joffe E: Inhibition of fibrinolysis by a synthetic urokinase inhibitor enhances lung colonization of metastatic murine mammary tumor cells. Oncol Rep 3: 1055-1058, 1996
APA
Alonso, D., Bertolesi, G., Farias, E., Gomez, D., & Joffe, E. (1996). Inhibition of fibrinolysis by a synthetic urokinase inhibitor enhances lung colonization of metastatic murine mammary tumor cells. Oncology Reports, 3, 1055-1058. https://doi.org/10.3892/or.3.6.1055
MLA
Alonso, D., Bertolesi, G., Farias, E., Gomez, D., Joffe, E."Inhibition of fibrinolysis by a synthetic urokinase inhibitor enhances lung colonization of metastatic murine mammary tumor cells". Oncology Reports 3.6 (1996): 1055-1058.
Chicago
Alonso, D., Bertolesi, G., Farias, E., Gomez, D., Joffe, E."Inhibition of fibrinolysis by a synthetic urokinase inhibitor enhances lung colonization of metastatic murine mammary tumor cells". Oncology Reports 3, no. 6 (1996): 1055-1058. https://doi.org/10.3892/or.3.6.1055