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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1996 Volume 3 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1996 Volume 3 Issue 6

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Article

TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas

  • Authors:
    • C Rossi
    • M Foletto
    • A Vecchiato
    • N Menin
    • E Pizzirani
    • F Di Filippo
    • M Vaglini
    • M Santinami
    • A Azzarelli
    • R Cavaliere
    • M Lise

  • View Affiliations / Copyright

    Affiliations: UNIV PADUA,IST ANESTESIA & RIANIMAZ,PADUA,ITALY. IST REGINA ELENA,I-00161 ROME,ITALY. IST NAZL TUMORI,I-20133 MILAN,ITALY.
  • Pages: 1059-1061
    |
    Published online on: November 1, 1996
       https://doi.org/10.3892/or.3.6.1059
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Abstract

Eighteen patients, subdivided into groups of three, were perfused for 90 min with escalating doses of TNF-alpha (0.5-3.3 mg) and standard doses of doxorubicin (bolus 0.7-1.4 mg/kg) at a tumor temperature of at least 41 degrees C, with the aim to ascertain the maximum tolerable dose (MTD) and the activity of TNF-alpha combined with doxorubicin in hyperthermic antiblastic perfusion (HAP) for patients with limb sarcomas, candidates for amputation. Tumor response was assessed both pathologically and radiologically. Severe systemic toxicity (WHO) was observed in only 2 patients. Locoregional toxicity (Wieberdink's) was grade I in 3 patients, grade II or III in 10 and grade IV in 5. A strict correlation between the TNF dosage and the grade of limb reaction was found, grade IV being retrieved only with TNF dose >1 mg and/or muscular temperature >41.5 degrees C. Tumor necrosis was evaluated in 16 patients: in 11 (68.8%) it scored more than 75% while in 5 it was 25 to 75%. Four cases (25%) had 100% tumor histological necrosis. Limb sparing surgery was feasible in 13 (81%). Our findings suggest that this is a well-tolerated and highly active regimen in HAP.

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Copy and paste a formatted citation
Spandidos Publications style
Rossi C, Foletto M, Vecchiato A, Menin N, Pizzirani E, Di Filippo F, Vaglini M, Santinami M, Azzarelli A, Cavaliere R, Cavaliere R, et al: TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas. Oncol Rep 3: 1059-1061, 1996.
APA
Rossi, C., Foletto, M., Vecchiato, A., Menin, N., Pizzirani, E., Di Filippo, F. ... Lise, M. (1996). TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas. Oncology Reports, 3, 1059-1061. https://doi.org/10.3892/or.3.6.1059
MLA
Rossi, C., Foletto, M., Vecchiato, A., Menin, N., Pizzirani, E., Di Filippo, F., Vaglini, M., Santinami, M., Azzarelli, A., Cavaliere, R., Lise, M."TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas". Oncology Reports 3.6 (1996): 1059-1061.
Chicago
Rossi, C., Foletto, M., Vecchiato, A., Menin, N., Pizzirani, E., Di Filippo, F., Vaglini, M., Santinami, M., Azzarelli, A., Cavaliere, R., Lise, M."TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas". Oncology Reports 3, no. 6 (1996): 1059-1061. https://doi.org/10.3892/or.3.6.1059
Copy and paste a formatted citation
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Spandidos Publications style
Rossi C, Foletto M, Vecchiato A, Menin N, Pizzirani E, Di Filippo F, Vaglini M, Santinami M, Azzarelli A, Cavaliere R, Cavaliere R, et al: TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas. Oncol Rep 3: 1059-1061, 1996.
APA
Rossi, C., Foletto, M., Vecchiato, A., Menin, N., Pizzirani, E., Di Filippo, F. ... Lise, M. (1996). TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas. Oncology Reports, 3, 1059-1061. https://doi.org/10.3892/or.3.6.1059
MLA
Rossi, C., Foletto, M., Vecchiato, A., Menin, N., Pizzirani, E., Di Filippo, F., Vaglini, M., Santinami, M., Azzarelli, A., Cavaliere, R., Lise, M."TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas". Oncology Reports 3.6 (1996): 1059-1061.
Chicago
Rossi, C., Foletto, M., Vecchiato, A., Menin, N., Pizzirani, E., Di Filippo, F., Vaglini, M., Santinami, M., Azzarelli, A., Cavaliere, R., Lise, M."TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas". Oncology Reports 3, no. 6 (1996): 1059-1061. https://doi.org/10.3892/or.3.6.1059
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