Expression of Fas in female reproductive tract tumors

  • Authors:
    • T Fuseya
    • A Imai
    • S Horibe
    • A Takagi
    • T Ohno
    • T Tamaya
  • View Affiliations

  • Published online on: November 1, 1996     https://doi.org/10.3892/or.3.6.1107
  • Pages: 1107-1109
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Fas, a cell surface receptor, mediates cell death by means of apoptosis in a variety of cell types. We attempted to detect Fas within plasma membrane isolated from surgically removed female reproductive tract tumors. Eight of 9 endometrial carcinomas and all ovarian carcinoma tested expressed Fas mRNA as assessed by RT-PCR using oligonucleotide primers according to published sequences. Immunoblotting of membrane proteins with the specific antibodies detected an immunoreactive Fas in 15 of the 16 tumors tested. In contrast, none of 9 uterine cervical carcinomas demonstrated Fas expression. Fas was expressed in a wide range of the carcinomas originating from the uterine endometrium and ovary, but not in the uterine cervix-derived tumors. Despite a poorly understood processes of apoptosis at present, this may suggest frequent expression of Fas in adenocarcinoma histologic types.

Related Articles

Journal Cover

November 1996
Volume 3 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Fuseya T, Imai A, Horibe S, Takagi A, Ohno T and Tamaya T: Expression of Fas in female reproductive tract tumors. Oncol Rep 3: 1107-1109, 1996
APA
Fuseya, T., Imai, A., Horibe, S., Takagi, A., Ohno, T., & Tamaya, T. (1996). Expression of Fas in female reproductive tract tumors. Oncology Reports, 3, 1107-1109. https://doi.org/10.3892/or.3.6.1107
MLA
Fuseya, T., Imai, A., Horibe, S., Takagi, A., Ohno, T., Tamaya, T."Expression of Fas in female reproductive tract tumors". Oncology Reports 3.6 (1996): 1107-1109.
Chicago
Fuseya, T., Imai, A., Horibe, S., Takagi, A., Ohno, T., Tamaya, T."Expression of Fas in female reproductive tract tumors". Oncology Reports 3, no. 6 (1996): 1107-1109. https://doi.org/10.3892/or.3.6.1107