Bradykinin stimulation does not induce intracellular Ca2+ elevation in cells from desmoid tumors
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- Published online on: November 1, 1996 https://doi.org/10.3892/or.3.6.1161
- Pages: 1161-1163
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Abstract
The intracellular mechanisms controlling cell proliferation in desmoid tumors (DT) are unknown. Bradykinin stimulated an increase in [Ca2+](i), (monitored by the fura-2 fluorescence) in fibroblasts obtained from both the skin of a normal donor and the mesenter of a familial adenomatous polyposis (FAP) patient. Cells from DT of the same patient as well as those from another FAP patient failed to show the elevation of [Ca2+](i) usually caused by bradykinin stimulation.
