Paclitaxel (taxol) in pretreated, relapsed and/or metastatic adult soft tissue sarcomas (STS)

  • Authors:
    • R Palumbo
    • P Raffo
    • C Capello
    • B Castagneto
    • C Gatti
    • S Toma
  • View Affiliations

  • Published online on: January 1, 1997     https://doi.org/10.3892/or.4.1.127
  • Pages: 127-130
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Abstract

Twelve patients suffering from recurrent or metastatic, previously treated, STS were given paclitaxel as a 3-hour infusion, with prophylactic medication, in 3-week cycles, at two different dosages: 135 mg/m(2) or 175 mg/m(2) in patients pretreated with less than or equal to 2 or greater than or equal to 3 chemotherapy regimens, respectively. A total of 39 courses was given (median 3, range 2-5). Overall, treatment was relatively well tolerated, major toxicity consisting of grade 2-3 neutropenia (33%); The adopted schedule was feasible in day-hospital setting, with satisfactory patient compliance. Only a partial response was obtained (8%), lasting 4 months; six patients had stable disease and five progressed while on treatment. Our results suggest a lack of activity of paclitaxel in this tumor type. However, the very advanced stage of disease and the strong pretreatment in the evaluated series probably partially account for some of the resistance and such a poor response rate. Further studies might be appropriate with paclitaxel, alone or in combination with other agents, on selected patients in less advanced stage of disease.

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January 1997
Volume 4 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Palumbo R, Raffo P, Capello C, Castagneto B, Gatti C and Toma S: Paclitaxel (taxol) in pretreated, relapsed and/or metastatic adult soft tissue sarcomas (STS). Oncol Rep 4: 127-130, 1997
APA
Palumbo, R., Raffo, P., Capello, C., Castagneto, B., Gatti, C., & Toma, S. (1997). Paclitaxel (taxol) in pretreated, relapsed and/or metastatic adult soft tissue sarcomas (STS). Oncology Reports, 4, 127-130. https://doi.org/10.3892/or.4.1.127
MLA
Palumbo, R., Raffo, P., Capello, C., Castagneto, B., Gatti, C., Toma, S."Paclitaxel (taxol) in pretreated, relapsed and/or metastatic adult soft tissue sarcomas (STS)". Oncology Reports 4.1 (1997): 127-130.
Chicago
Palumbo, R., Raffo, P., Capello, C., Castagneto, B., Gatti, C., Toma, S."Paclitaxel (taxol) in pretreated, relapsed and/or metastatic adult soft tissue sarcomas (STS)". Oncology Reports 4, no. 1 (1997): 127-130. https://doi.org/10.3892/or.4.1.127