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Frequent microsatellite instability in oral cancer

  • Authors:
    • K Ogawara
    • K Uzawa
    • H Nakanishi
    • H Yokoe
    • X Wang
    • H Tanzawa
    • K Sato

  • View Affiliations

  • Published online on: January 1, 1997     https://doi.org/10.3892/or.4.1.161
  • Pages: 161-165
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Abstract

In oder to confirm whether microsatellite instability (MI) contributes to oral carcinogenesis, we studied 30 unrelated patients with oral cancer by PCR-MI assay with 14 microsatellite markers. MI was detected in 60% of 30 primary tumors. Tn particular, 12 of these cases presented at least two loci with MI, which were considered as patients with replication error (RER). Moreover, an additional MI, which was not observed in the primary tumor and normal tissue, was observed in one lymph node metastasis. We found significant correlation between RER and lymph node metastasis. These results suggest that RER is a common event in the oncogenesis of oral cancer and may be correlated with the progression of this disease.

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Journal Cover

January 1997
Volume 4 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Ogawara K, Uzawa K, Nakanishi H, Yokoe H, Wang X, Tanzawa H and Sato K: Frequent microsatellite instability in oral cancer. Oncol Rep 4: 161-165, 1997
APA
Ogawara, K., Uzawa, K., Nakanishi, H., Yokoe, H., Wang, X., Tanzawa, H., & Sato, K. (1997). Frequent microsatellite instability in oral cancer. Oncology Reports, 4, 161-165. https://doi.org/10.3892/or.4.1.161
MLA
Ogawara, K., Uzawa, K., Nakanishi, H., Yokoe, H., Wang, X., Tanzawa, H., Sato, K."Frequent microsatellite instability in oral cancer". Oncology Reports 4.1 (1997): 161-165.
Chicago
Ogawara, K., Uzawa, K., Nakanishi, H., Yokoe, H., Wang, X., Tanzawa, H., Sato, K."Frequent microsatellite instability in oral cancer". Oncology Reports 4, no. 1 (1997): 161-165. https://doi.org/10.3892/or.4.1.161