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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
January 1997 Volume 4 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January 1997 Volume 4 Issue 1

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Article

Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma

  • Authors:
    • G Pietra
    • C Semino
    • S Basso
    • M Gipponi
    • G DiSomma
    • A Peressini
    • F Cafiero
    • M Ponte
    • P Queirolo
    • I Ribizzi
    • M Sertoli
    • G Melioli
  • View Affiliations / Copyright

    Affiliations: IST NAZL RIC CANC,DIV ONCOL CHIRURG,I-16132 GENOA,ITALY. UNIV GENOA,IST ONCOL CLIN,GENOA,ITALY. IST NAZL RIC CANC,SERV PATOL CLIN,I-16132 GENOA,ITALY.
  • Pages: 27-31
    |
    Published online on: January 1, 1997
       https://doi.org/10.3892/or.4.1.27
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Abstract

Adoptive immunotherapy with in vitro expanded tumor infiltrating lymphocytes (TIL) and recombinant interleukin-2 (rIL-2) is a recent option in the treatment of advanced melanoma resistant to conventional chemotherapy. In the course of a protocol of treatment of advanced melanoma with in vitro expanded TIL and rIL-2, we obtained 38 samples from 27 different patients. Lymphocytes derived were cultured in the presence of rIL-2 in vitro for a 4-6 week period and 23 resulted in proliferative cultures. Eighteen samples were infused in the course of the clinical trial. The median number of lymphocytes obtained was 18x10(9) (range 1-43x10(9)) cells. Phenotypic analysis showed that all samples contained a pure population of T cells. These data confirm that lymphocytes can be expanded from advanced metastatic sites, have peculiar characteristics and are suitable to be infused in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Pietra G, Semino C, Basso S, Gipponi M, DiSomma G, Peressini A, Cafiero F, Ponte M, Queirolo P, Ribizzi I, Ribizzi I, et al: Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma. Oncol Rep 4: 27-31, 1997.
APA
Pietra, G., Semino, C., Basso, S., Gipponi, M., DiSomma, G., Peressini, A. ... Melioli, G. (1997). Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma. Oncology Reports, 4, 27-31. https://doi.org/10.3892/or.4.1.27
MLA
Pietra, G., Semino, C., Basso, S., Gipponi, M., DiSomma, G., Peressini, A., Cafiero, F., Ponte, M., Queirolo, P., Ribizzi, I., Sertoli, M., Melioli, G."Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma". Oncology Reports 4.1 (1997): 27-31.
Chicago
Pietra, G., Semino, C., Basso, S., Gipponi, M., DiSomma, G., Peressini, A., Cafiero, F., Ponte, M., Queirolo, P., Ribizzi, I., Sertoli, M., Melioli, G."Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma". Oncology Reports 4, no. 1 (1997): 27-31. https://doi.org/10.3892/or.4.1.27
Copy and paste a formatted citation
x
Spandidos Publications style
Pietra G, Semino C, Basso S, Gipponi M, DiSomma G, Peressini A, Cafiero F, Ponte M, Queirolo P, Ribizzi I, Ribizzi I, et al: Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma. Oncol Rep 4: 27-31, 1997.
APA
Pietra, G., Semino, C., Basso, S., Gipponi, M., DiSomma, G., Peressini, A. ... Melioli, G. (1997). Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma. Oncology Reports, 4, 27-31. https://doi.org/10.3892/or.4.1.27
MLA
Pietra, G., Semino, C., Basso, S., Gipponi, M., DiSomma, G., Peressini, A., Cafiero, F., Ponte, M., Queirolo, P., Ribizzi, I., Sertoli, M., Melioli, G."Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma". Oncology Reports 4.1 (1997): 27-31.
Chicago
Pietra, G., Semino, C., Basso, S., Gipponi, M., DiSomma, G., Peressini, A., Cafiero, F., Ponte, M., Queirolo, P., Ribizzi, I., Sertoli, M., Melioli, G."Analysis of the proliferative and phenotypic properties of tumor infiltrating lymphocytes expanded in vitro in the course of the clinical trial of adoptive immunotherapy of metastatic melanoma". Oncology Reports 4, no. 1 (1997): 27-31. https://doi.org/10.3892/or.4.1.27
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