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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 1997 Volume 4 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1997 Volume 4 Issue 1

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Article

Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract

  • Authors:
    • K Ohta
    • M Kuwahara
    • N Fujisaki
    • S Kagawa
    • M Furihata
    • Y Ohtsuki

  • View Affiliations / Copyright

    Affiliations: UNIV TOKUSHIMA,SCH MED,DEPT UROL,TOKUSHIMA 770,JAPAN. KOCHI MED SCH,DEPT PATHOL 2,NANKO KU,KOCHI 783,JAPAN.
  • Pages: 97-101
    |
    Published online on: January 1, 1997
       https://doi.org/10.3892/or.4.1.97
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Abstract

We employed immunohistochemical methods to investigate the overexpression of cyclin D1 protein as well as p53 protein and retinoblastoma protein (pRb) in 57 patients with transitional cell carcinoma (TCC) of the urinary tract, in order to determine their frequency and significance, and also association with the clinicopathological behavior of this tumor. Nuclear immunostaining with cyclin D1 antibody revealed 7 homogeneously stained tumors (12.3%), including 4 heterogeneous pRb expressions, of which only one was also positive for p53. Positive immunostaining with each antibody to p53 or pRb was obtained in 15 (26.3%) and 49 (86%) tumors, respectively. The 49 pRb-positive tumors included 6 homogeneous and 43 heterogeneous nuclear immunostaining patterns. The remaining pRb-negative 8 tumors included 5 cyclin D1-negative tumors. The prevalence of p53 staining was higher in high-grade (P<0.05) and invasive types of tumors (P<0.05) than the other types studied. On the other hand, no significant relationship was found between cyclin D1- or pRb-immunoreactivity and clinicopathological factors. These findings provide evidence for infrequent cyclin D1 protein overexpression in TCC independently associated with p53 protein and/or pRb overexpression.

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Copy and paste a formatted citation
Spandidos Publications style
Ohta K, Kuwahara M, Fujisaki N, Kagawa S, Furihata M and Ohtsuki Y: Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract. Oncol Rep 4: 97-101, 1997.
APA
Ohta, K., Kuwahara, M., Fujisaki, N., Kagawa, S., Furihata, M., & Ohtsuki, Y. (1997). Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract. Oncology Reports, 4, 97-101. https://doi.org/10.3892/or.4.1.97
MLA
Ohta, K., Kuwahara, M., Fujisaki, N., Kagawa, S., Furihata, M., Ohtsuki, Y."Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract". Oncology Reports 4.1 (1997): 97-101.
Chicago
Ohta, K., Kuwahara, M., Fujisaki, N., Kagawa, S., Furihata, M., Ohtsuki, Y."Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract". Oncology Reports 4, no. 1 (1997): 97-101. https://doi.org/10.3892/or.4.1.97
Copy and paste a formatted citation
x
Spandidos Publications style
Ohta K, Kuwahara M, Fujisaki N, Kagawa S, Furihata M and Ohtsuki Y: Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract. Oncol Rep 4: 97-101, 1997.
APA
Ohta, K., Kuwahara, M., Fujisaki, N., Kagawa, S., Furihata, M., & Ohtsuki, Y. (1997). Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract. Oncology Reports, 4, 97-101. https://doi.org/10.3892/or.4.1.97
MLA
Ohta, K., Kuwahara, M., Fujisaki, N., Kagawa, S., Furihata, M., Ohtsuki, Y."Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract". Oncology Reports 4.1 (1997): 97-101.
Chicago
Ohta, K., Kuwahara, M., Fujisaki, N., Kagawa, S., Furihata, M., Ohtsuki, Y."Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract". Oncology Reports 4, no. 1 (1997): 97-101. https://doi.org/10.3892/or.4.1.97
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