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The clinical implications of glutathione S-transferase-pi expression in lung cancer

  • Authors:
    • S Fujino
    • M Oka
    • A Sakamoto
    • M Fukuda
    • H Takatani
    • K Terashi
    • F Narasaki
    • K Ikeda
    • Y Inoue
    • A Kinoshita
    • H Soda
    • T Kanda
    • S Kohno

  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.311
  • Pages: 311-313
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Abstract

We performed immunohistochemical staining of glutathione S-transferase-pi (GST-pi) in 97 lung cancer specimens. In untreated patients, 86% (48/56) of NSCLC and none (0/8) of SCLC stained for GST-pi, and all squamous cell carcinomas were positive (28/28). The proportion of positive NSCLC with preoperative chemotherapy was similar to that of the untreated NSCLC, but the proportion of treated SCLC positive for GST-pi (14/18) was significantly higher than untreated tumors. GST-pi in NSCLC may be a tumor marker rather than being involved in drug resistance, and GST-pi-induction by chemotherapy may relate to acquired resistance in SCLC.

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March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Fujino S, Oka M, Sakamoto A, Fukuda M, Takatani H, Terashi K, Narasaki F, Ikeda K, Inoue Y, Kinoshita A, Kinoshita A, et al: The clinical implications of glutathione S-transferase-pi expression in lung cancer. Oncol Rep 4: 311-313, 1997
APA
Fujino, S., Oka, M., Sakamoto, A., Fukuda, M., Takatani, H., Terashi, K. ... Kohno, S. (1997). The clinical implications of glutathione S-transferase-pi expression in lung cancer. Oncology Reports, 4, 311-313. https://doi.org/10.3892/or.4.2.311
MLA
Fujino, S., Oka, M., Sakamoto, A., Fukuda, M., Takatani, H., Terashi, K., Narasaki, F., Ikeda, K., Inoue, Y., Kinoshita, A., Soda, H., Kanda, T., Kohno, S."The clinical implications of glutathione S-transferase-pi expression in lung cancer". Oncology Reports 4.2 (1997): 311-313.
Chicago
Fujino, S., Oka, M., Sakamoto, A., Fukuda, M., Takatani, H., Terashi, K., Narasaki, F., Ikeda, K., Inoue, Y., Kinoshita, A., Soda, H., Kanda, T., Kohno, S."The clinical implications of glutathione S-transferase-pi expression in lung cancer". Oncology Reports 4, no. 2 (1997): 311-313. https://doi.org/10.3892/or.4.2.311