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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 1997 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1997 Volume 4 Issue 2

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Article

Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer

  • Authors:
    • T Sugiyama
    • M Yakushiji
    • T Nishida

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 345-348
    |
    Published online on: March 1, 1997
       https://doi.org/10.3892/or.4.2.345
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Abstract

As CPT-11 was shown to be efficacious in recurrent ovarian cancer, a phase II trial has been undertaken at a recommended dose determined in the phase I trials of combination therapy of CPT-11 with cisplatin (CDDP). As first-line chemotherapy, 60 mg/m(2) of CPT-11 (on days 1, 8, and 15) and 60 mg/m(2) of CDDP (on day 1) were intravenously administered to patients with epithelial ovarian cancer with residual lesions larger than 2 cm, and patients who underwent exploratory laparotomy. Case 1 and 2 achieved CR and PR after completion of the first and second courses, respectively. After the third course when CA125 values turned negative, secondary cytoreductive surgery was performed in both cases, and the tumor was completely extirpated. Dose limiting toxicity was neutropenia, which was managed by administration of granulocyte stimulating factor or by skipping the administration of CPT-11. In Case 2, the number of platelets decreased with repetition of the courses. Grade 3 or worse diarrhea was not observed. The combination therapy of CPT-11 with CDDP is considered to be safe and efficacious in treatment of epithelial ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sugiyama T, Yakushiji M and Nishida T: Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer. Oncol Rep 4: 345-348, 1997.
APA
Sugiyama, T., Yakushiji, M., & Nishida, T. (1997). Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer. Oncology Reports, 4, 345-348. https://doi.org/10.3892/or.4.2.345
MLA
Sugiyama, T., Yakushiji, M., Nishida, T."Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer". Oncology Reports 4.2 (1997): 345-348.
Chicago
Sugiyama, T., Yakushiji, M., Nishida, T."Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer". Oncology Reports 4, no. 2 (1997): 345-348. https://doi.org/10.3892/or.4.2.345
Copy and paste a formatted citation
x
Spandidos Publications style
Sugiyama T, Yakushiji M and Nishida T: Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer. Oncol Rep 4: 345-348, 1997.
APA
Sugiyama, T., Yakushiji, M., & Nishida, T. (1997). Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer. Oncology Reports, 4, 345-348. https://doi.org/10.3892/or.4.2.345
MLA
Sugiyama, T., Yakushiji, M., Nishida, T."Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer". Oncology Reports 4.2 (1997): 345-348.
Chicago
Sugiyama, T., Yakushiji, M., Nishida, T."Combination of CPT-11 with cisplatin as first-line chemotherapy in advanced epithelial ovarian cancer". Oncology Reports 4, no. 2 (1997): 345-348. https://doi.org/10.3892/or.4.2.345
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