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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May 1997 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 1997 Volume 4 Issue 3

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Article

Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line

  • Authors:
    • A Koura
    • K VanGolen
    • R Tsan
    • R Radinsky
    • J Price
    • L Ellis

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT SURG ONCOL,HOUSTON,TX 77030. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT CELL BIOL,HOUSTON,TX 77030.
  • Pages: 475-479
    |
    Published online on: May 1, 1997
       https://doi.org/10.3892/or.4.3.475
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Abstract

K1735 murine melanoma cells transfected with p53 cDNAs bearing specific point mutations are metastatic in nude mice, whereas the parent and control-transfected cells are nonmetastatic. To determine whether p53 gene mutations regulate genes associated with angiogenesis, growth, and metastasis, we examined expression of vascular endothelial growth factor I, IGF-I receptor, epidermal growth factor insulin-like growth factor I, IGF-I receptor, epidermal growth factor receptor, c-MET, and thrombospondin 1 in K1735 cells transfected with one of four different mutant p53 cDNAs. Northern blot analysis demonstrated differential upregulation of these genes in cells transfected with different mutant p53 cDNAs. Up-regulation of angiogenesis-, growth-, and metastasis-related genes by mutant p53 may contribute to metastasis formation.

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Copy and paste a formatted citation
Spandidos Publications style
Koura A, VanGolen K, Tsan R, Radinsky R, Price J and Ellis L: Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line. Oncol Rep 4: 475-479, 1997.
APA
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., & Ellis, L. (1997). Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line. Oncology Reports, 4, 475-479. https://doi.org/10.3892/or.4.3.475
MLA
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., Ellis, L."Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line". Oncology Reports 4.3 (1997): 475-479.
Chicago
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., Ellis, L."Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line". Oncology Reports 4, no. 3 (1997): 475-479. https://doi.org/10.3892/or.4.3.475
Copy and paste a formatted citation
x
Spandidos Publications style
Koura A, VanGolen K, Tsan R, Radinsky R, Price J and Ellis L: Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line. Oncol Rep 4: 475-479, 1997.
APA
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., & Ellis, L. (1997). Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line. Oncology Reports, 4, 475-479. https://doi.org/10.3892/or.4.3.475
MLA
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., Ellis, L."Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line". Oncology Reports 4.3 (1997): 475-479.
Chicago
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., Ellis, L."Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line". Oncology Reports 4, no. 3 (1997): 475-479. https://doi.org/10.3892/or.4.3.475
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