Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line

  • Authors:
    • A Koura
    • K VanGolen
    • R Tsan
    • R Radinsky
    • J Price
    • L Ellis
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.475
  • Pages: 475-479
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Abstract

K1735 murine melanoma cells transfected with p53 cDNAs bearing specific point mutations are metastatic in nude mice, whereas the parent and control-transfected cells are nonmetastatic. To determine whether p53 gene mutations regulate genes associated with angiogenesis, growth, and metastasis, we examined expression of vascular endothelial growth factor I, IGF-I receptor, epidermal growth factor insulin-like growth factor I, IGF-I receptor, epidermal growth factor receptor, c-MET, and thrombospondin 1 in K1735 cells transfected with one of four different mutant p53 cDNAs. Northern blot analysis demonstrated differential upregulation of these genes in cells transfected with different mutant p53 cDNAs. Up-regulation of angiogenesis-, growth-, and metastasis-related genes by mutant p53 may contribute to metastasis formation.

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May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Koura A, VanGolen K, Tsan R, Radinsky R, Price J and Ellis L: Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line. Oncol Rep 4: 475-479, 1997.
APA
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., & Ellis, L. (1997). Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line. Oncology Reports, 4, 475-479. https://doi.org/10.3892/or.4.3.475
MLA
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., Ellis, L."Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line". Oncology Reports 4.3 (1997): 475-479.
Chicago
Koura, A., VanGolen, K., Tsan, R., Radinsky, R., Price, J., Ellis, L."Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line". Oncology Reports 4, no. 3 (1997): 475-479. https://doi.org/10.3892/or.4.3.475