Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis

  • Authors:
    • Y Nakagawa
    • Y Ando
    • N Fujimoto
    • Y Masaoka
    • M Tanizaki
    • S Syoji
    • O Katoh
    • H Watanabe
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.517
  • Pages: 517-519
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Abstract

The present study was undertaken to determine the response of colon mucosa implanted into the fundus of stomach in 6-week old male F344 rats to oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Samples of colonic tissue about 8 mm in diameter were obtained from various colon sites and surgically implanted into the anterior wall of the fundus by isografting. MNNG was chronically administered at a concentration of 100 mg/l in the drinking water for 16 weeks starting 4 weeks after the operation and the grafted colon mucosa was examined at 12 months after the operation. Control rats received a sham-operation and the same amount of MNNG. In the MNNG administered groups, only one adenoma containing Paneth cells was noted in the implanted colon tissue whereas over 40% incidence of gastric tumors was observed in the pyloric mucosa. In the operated rats not given MNNG no gastric tumors were observed in either the grafted site or the pylorus.

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May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nakagawa Y, Ando Y, Fujimoto N, Masaoka Y, Tanizaki M, Syoji S, Katoh O and Watanabe H: Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis. Oncol Rep 4: 517-519, 1997
APA
Nakagawa, Y., Ando, Y., Fujimoto, N., Masaoka, Y., Tanizaki, M., Syoji, S. ... Watanabe, H. (1997). Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis. Oncology Reports, 4, 517-519. https://doi.org/10.3892/or.4.3.517
MLA
Nakagawa, Y., Ando, Y., Fujimoto, N., Masaoka, Y., Tanizaki, M., Syoji, S., Katoh, O., Watanabe, H."Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis". Oncology Reports 4.3 (1997): 517-519.
Chicago
Nakagawa, Y., Ando, Y., Fujimoto, N., Masaoka, Y., Tanizaki, M., Syoji, S., Katoh, O., Watanabe, H."Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis". Oncology Reports 4, no. 3 (1997): 517-519. https://doi.org/10.3892/or.4.3.517