Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis

  • Authors:
    • Y Nakagawa
    • Y Ando
    • N Fujimoto
    • Y Masaoka
    • M Tanizaki
    • S Syoji
    • O Katoh
    • H Watanabe
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.517
  • Pages: 517-519
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study was undertaken to determine the response of colon mucosa implanted into the fundus of stomach in 6-week old male F344 rats to oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Samples of colonic tissue about 8 mm in diameter were obtained from various colon sites and surgically implanted into the anterior wall of the fundus by isografting. MNNG was chronically administered at a concentration of 100 mg/l in the drinking water for 16 weeks starting 4 weeks after the operation and the grafted colon mucosa was examined at 12 months after the operation. Control rats received a sham-operation and the same amount of MNNG. In the MNNG administered groups, only one adenoma containing Paneth cells was noted in the implanted colon tissue whereas over 40% incidence of gastric tumors was observed in the pyloric mucosa. In the operated rats not given MNNG no gastric tumors were observed in either the grafted site or the pylorus.

Related Articles

Journal Cover

May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Nakagawa Y, Ando Y, Fujimoto N, Masaoka Y, Tanizaki M, Syoji S, Katoh O and Watanabe H: Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis. Oncol Rep 4: 517-519, 1997.
APA
Nakagawa, Y., Ando, Y., Fujimoto, N., Masaoka, Y., Tanizaki, M., Syoji, S. ... Watanabe, H. (1997). Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis. Oncology Reports, 4, 517-519. https://doi.org/10.3892/or.4.3.517
MLA
Nakagawa, Y., Ando, Y., Fujimoto, N., Masaoka, Y., Tanizaki, M., Syoji, S., Katoh, O., Watanabe, H."Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis". Oncology Reports 4.3 (1997): 517-519.
Chicago
Nakagawa, Y., Ando, Y., Fujimoto, N., Masaoka, Y., Tanizaki, M., Syoji, S., Katoh, O., Watanabe, H."Colon tissue implanted into the glandular stomach in rats lack susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) carcinogenesis". Oncology Reports 4, no. 3 (1997): 517-519. https://doi.org/10.3892/or.4.3.517