Possible association between immunocompetence and enhanced risk of multicentric carcinogenesis in both the stomach and other organs in patients with gastric cancer

  • Authors:
    • M Maeta
    • N Shimizu
    • K Katano
    • H Saito
    • S Tsujitani
    • M Ikeguchi
    • N Kaibara
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.557
  • Pages: 557-560
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Abstract

In a retrospective study, we analyzed the association between the immunocompetence and multicentric carcinogenesis in both the stomach and organs other than the stomach in patients with single gastric cancer (SGC) and those with multiple gastric cancers (MGC). The incidence of primary cancers in other organs in patients with MGC (4/17, 23.5%) was significantly higher than that with SGC (15/202, 7.4%). Our analysis of the immunocompetence revealed a trend towards decreased activity of NK cells and of mitogen-induced blastogenesis in patients with MGC as compared to those with SGC. In patients with SGC, patients with primary cancers in other organs had significantly lower levels of both PHA-induced blastogenesis and CD4/CDs, and revealed a greater trend towards decreased activity of both NK cells and Con A-induced blastogenesis than patients without other primary cancers. These findings may suggest that immunocompetence plays a role in the enhanced multicentric carcinogenesis not only in the stomach but also in cancers of other organs.

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May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Maeta M, Shimizu N, Katano K, Saito H, Tsujitani S, Ikeguchi M and Kaibara N: Possible association between immunocompetence and enhanced risk of multicentric carcinogenesis in both the stomach and other organs in patients with gastric cancer. Oncol Rep 4: 557-560, 1997
APA
Maeta, M., Shimizu, N., Katano, K., Saito, H., Tsujitani, S., Ikeguchi, M., & Kaibara, N. (1997). Possible association between immunocompetence and enhanced risk of multicentric carcinogenesis in both the stomach and other organs in patients with gastric cancer. Oncology Reports, 4, 557-560. https://doi.org/10.3892/or.4.3.557
MLA
Maeta, M., Shimizu, N., Katano, K., Saito, H., Tsujitani, S., Ikeguchi, M., Kaibara, N."Possible association between immunocompetence and enhanced risk of multicentric carcinogenesis in both the stomach and other organs in patients with gastric cancer". Oncology Reports 4.3 (1997): 557-560.
Chicago
Maeta, M., Shimizu, N., Katano, K., Saito, H., Tsujitani, S., Ikeguchi, M., Kaibara, N."Possible association between immunocompetence and enhanced risk of multicentric carcinogenesis in both the stomach and other organs in patients with gastric cancer". Oncology Reports 4, no. 3 (1997): 557-560. https://doi.org/10.3892/or.4.3.557