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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 1997 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1997 Volume 4 Issue 3

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Article

Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas

  • Authors:
    • B Liang
    • P Kish
    • D Ross

  • View Affiliations / Copyright

    Affiliations: UNIV COLORADO,HLTH SCI CTR,DEPT MED MED ONCOL,DENVER,CO 80262. UNIV COLORADO,HLTH SCI CTR,DEPT PATHOL,DENVER,CO 80262. UNIV MICHIGAN,SCH MED,DEPT SURG,NEUROSURG SECT,ANN ARBOR,MI 48109.
  • Pages: 613-617
    |
    Published online on: May 1, 1997
       https://doi.org/10.3892/or.4.3.613
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Abstract

Our recent studies have shown that telomeric 10p is frequently deleted in both low and high grade gliomas. Other studies have shown an invariant association of erb-b amplification and loss of chromosome 10. It has not been determined whether this association was specific for a particular locus on chromosome 10. We sought to assess this by examining tumors, for both 10p loss and gene amplification. 55% of tumors showed some degree of allelic imbalance at 10p15. Amplification of erb-b, c-myc, and a mitochondrial cDNA probe, recently found to be amplified in diverse grades of gliomas was assessed. erb-b and the mitochondrial cDNA probe showed amplification in 28% of the tumors; c-myc gene was amplified in only one astrocytoma. No significant association was noted when comparing the presence of a specific amplified gene, and loss of loci on chromosome. Chromosome 10p15 shows significant loss in glial tumors, and is independent of the chromosome 10 region associated with erb-b amplification. The region at 10p15 is distinct in harboring a putative tumor suppressor gene in gliomas, and is involved earlier in the multi-step pathway to glial tumor malignancy.

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Copy and paste a formatted citation
Spandidos Publications style
Liang B, Kish P and Ross D: Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas. Oncol Rep 4: 613-617, 1997.
APA
Liang, B., Kish, P., & Ross, D. (1997). Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas. Oncology Reports, 4, 613-617. https://doi.org/10.3892/or.4.3.613
MLA
Liang, B., Kish, P., Ross, D."Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas". Oncology Reports 4.3 (1997): 613-617.
Chicago
Liang, B., Kish, P., Ross, D."Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas". Oncology Reports 4, no. 3 (1997): 613-617. https://doi.org/10.3892/or.4.3.613
Copy and paste a formatted citation
x
Spandidos Publications style
Liang B, Kish P and Ross D: Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas. Oncol Rep 4: 613-617, 1997.
APA
Liang, B., Kish, P., & Ross, D. (1997). Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas. Oncology Reports, 4, 613-617. https://doi.org/10.3892/or.4.3.613
MLA
Liang, B., Kish, P., Ross, D."Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas". Oncology Reports 4.3 (1997): 613-617.
Chicago
Liang, B., Kish, P., Ross, D."Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas". Oncology Reports 4, no. 3 (1997): 613-617. https://doi.org/10.3892/or.4.3.613
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