Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas

  • Authors:
    • B Liang
    • P Kish
    • D Ross
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.613
  • Pages: 613-617
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Abstract

Our recent studies have shown that telomeric 10p is frequently deleted in both low and high grade gliomas. Other studies have shown an invariant association of erb-b amplification and loss of chromosome 10. It has not been determined whether this association was specific for a particular locus on chromosome 10. We sought to assess this by examining tumors, for both 10p loss and gene amplification. 55% of tumors showed some degree of allelic imbalance at 10p15. Amplification of erb-b, c-myc, and a mitochondrial cDNA probe, recently found to be amplified in diverse grades of gliomas was assessed. erb-b and the mitochondrial cDNA probe showed amplification in 28% of the tumors; c-myc gene was amplified in only one astrocytoma. No significant association was noted when comparing the presence of a specific amplified gene, and loss of loci on chromosome. Chromosome 10p15 shows significant loss in glial tumors, and is independent of the chromosome 10 region associated with erb-b amplification. The region at 10p15 is distinct in harboring a putative tumor suppressor gene in gliomas, and is involved earlier in the multi-step pathway to glial tumor malignancy.

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May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liang B, Kish P and Ross D: Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas. Oncol Rep 4: 613-617, 1997
APA
Liang, B., Kish, P., & Ross, D. (1997). Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas. Oncology Reports, 4, 613-617. https://doi.org/10.3892/or.4.3.613
MLA
Liang, B., Kish, P., Ross, D."Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas". Oncology Reports 4.3 (1997): 613-617.
Chicago
Liang, B., Kish, P., Ross, D."Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas". Oncology Reports 4, no. 3 (1997): 613-617. https://doi.org/10.3892/or.4.3.613