Diurnal rhythmicity of endogenous TNF alpha concentration in plasma of advanced gastrointestinal cancer patients

  • Authors:
    • M MucWierzgon
    • K Madej
    • M Baranowski
    • T Kokot
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.637
  • Pages: 637-640
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Abstract

The objective of this study was to test the hypothesis of a diurnal fluctuation of circulating levels of endogenous tumor necrosis factor alpha (TNF alpha) in patients with advanced gastrointestinal cancer. Serum levels of TNF alpha were measured at 8 am., 2 p.m., 6 p.m., 10 p.m., and 2 a.m, in 40 patients with advanced gastro-intestinal cancer. In the control group TNF alpha plasma levels were low and did not exhibit regular patterns. On the contrary serum TNF alpha levels were substantially increased in patients with advanced cancer. Peak value appeared at 2 a.m. In contrast, the levels were low in the afternoon (2 p.m.). The presence of circadian rhythm was found with an acrophase at 0 h 36 min.

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May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
MucWierzgon M, Madej K, Baranowski M and Kokot T: Diurnal rhythmicity of endogenous TNF alpha concentration in plasma of advanced gastrointestinal cancer patients. Oncol Rep 4: 637-640, 1997
APA
MucWierzgon, M., Madej, K., Baranowski, M., & Kokot, T. (1997). Diurnal rhythmicity of endogenous TNF alpha concentration in plasma of advanced gastrointestinal cancer patients. Oncology Reports, 4, 637-640. https://doi.org/10.3892/or.4.3.637
MLA
MucWierzgon, M., Madej, K., Baranowski, M., Kokot, T."Diurnal rhythmicity of endogenous TNF alpha concentration in plasma of advanced gastrointestinal cancer patients". Oncology Reports 4.3 (1997): 637-640.
Chicago
MucWierzgon, M., Madej, K., Baranowski, M., Kokot, T."Diurnal rhythmicity of endogenous TNF alpha concentration in plasma of advanced gastrointestinal cancer patients". Oncology Reports 4, no. 3 (1997): 637-640. https://doi.org/10.3892/or.4.3.637