De novo germline mutations of the p53 gene in young children with sarcomas

  • Authors:
    • I Ayan
    • J Luca
    • N Jaffe
    • L Strong
    • M Hansen
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/or.4.4.679
  • Pages: 679-683
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Abstract

Germline p53 mutations are associated with cancer predisposition in Li-Fraumeni families as well as in individuals with component tumors of the syndrome. In the majority of cases these mutations have been shown to be inherited rather than de novo. We screened 59 children with primary bone or soft tissue sarcomas. Germline p53 mutations were identified in 2 patients. Interestingly, analysis revealed that both mutations were de novo. Although the frequency of germline p53 mutations in primary pediatric sarcoma patients is low, there is evidence for the importance of considering pediatric patients for testing for de novo mutations.

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July 1997
Volume 4 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ayan I, Luca J, Jaffe N, Strong L and Hansen M: De novo germline mutations of the p53 gene in young children with sarcomas. Oncol Rep 4: 679-683, 1997
APA
Ayan, I., Luca, J., Jaffe, N., Strong, L., & Hansen, M. (1997). De novo germline mutations of the p53 gene in young children with sarcomas. Oncology Reports, 4, 679-683. https://doi.org/10.3892/or.4.4.679
MLA
Ayan, I., Luca, J., Jaffe, N., Strong, L., Hansen, M."De novo germline mutations of the p53 gene in young children with sarcomas". Oncology Reports 4.4 (1997): 679-683.
Chicago
Ayan, I., Luca, J., Jaffe, N., Strong, L., Hansen, M."De novo germline mutations of the p53 gene in young children with sarcomas". Oncology Reports 4, no. 4 (1997): 679-683. https://doi.org/10.3892/or.4.4.679