Lack of prognostic significance for p53-overexpression and Ki-67-immunoreactivity in oral T1-2 squamous cell carcinomas

  • Authors:
    • D Lange
    • A Heyden
    • E Lie
    • P Brandtzaeg
    • M Boysen
    • O Clausen
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/or.4.4.737
  • Pages: 737-742
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Abstract

Previous investigations on squamous cell carcinomas (SCC) of the head and neck region have failed to reveal a significant correlation between p53-overexpression or Ki-67-immunoreactivity and survival. Contrary to these studies we restricted the evaluation to T1-2 SCC from the oral cavity. Immunohistochemically identified p53-overexpression was observed in 69% of the tumours, and Ki-67-positive cancer cells ranged from 12 to 83% in individual rumours (median 37%). No significant correlation was found between p53-overexpression or Ki-67-positivity and survival. Although the degree of tumour differentiation and the pattern of invasion correlated with prognosis (p=0.0387 and 0.0319 respectively), these associations were too weak to be used as prognostic markers.

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July 1997
Volume 4 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lange D, Heyden A, Lie E, Brandtzaeg P, Boysen M and Clausen O: Lack of prognostic significance for p53-overexpression and Ki-67-immunoreactivity in oral T1-2 squamous cell carcinomas. Oncol Rep 4: 737-742, 1997
APA
Lange, D., Heyden, A., Lie, E., Brandtzaeg, P., Boysen, M., & Clausen, O. (1997). Lack of prognostic significance for p53-overexpression and Ki-67-immunoreactivity in oral T1-2 squamous cell carcinomas. Oncology Reports, 4, 737-742. https://doi.org/10.3892/or.4.4.737
MLA
Lange, D., Heyden, A., Lie, E., Brandtzaeg, P., Boysen, M., Clausen, O."Lack of prognostic significance for p53-overexpression and Ki-67-immunoreactivity in oral T1-2 squamous cell carcinomas". Oncology Reports 4.4 (1997): 737-742.
Chicago
Lange, D., Heyden, A., Lie, E., Brandtzaeg, P., Boysen, M., Clausen, O."Lack of prognostic significance for p53-overexpression and Ki-67-immunoreactivity in oral T1-2 squamous cell carcinomas". Oncology Reports 4, no. 4 (1997): 737-742. https://doi.org/10.3892/or.4.4.737