Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors

  • Authors:
    • H Chen
    • R Udelsman
    • M Zeiger
    • D Ball
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/or.4.4.775
  • Pages: 775-778
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Abstract

Human achaete-scute homolog-1 (hASH1) is critical for establishing the neuroendocrine (NE) phenotype of small cell lung cancer. To define its role in other neoplasms, we analyzed 33 tumors for hASH1 by Northern blotting. Significant levels of hASH1 mRNA were detected in 4 pheochromocytomas, 2 medullary thyroid cancers, and 1 thymic carcinoid. hASH1 transcripts were undetectable in 8 parathyroid lesions, 6 gastrinomas, 4 insulinomas, and 7 thyroid neoplasms, as well as in normal thyroid, adrenal, or pancreas tissue. Therefore, hASH1 mRNA is highly abundant in a subset of human tumors and may play a role in dictating their NE phenotype.

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July 1997
Volume 4 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Chen H, Udelsman R, Zeiger M and Ball D: Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors. Oncol Rep 4: 775-778, 1997
APA
Chen, H., Udelsman, R., Zeiger, M., & Ball, D. (1997). Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors. Oncology Reports, 4, 775-778. https://doi.org/10.3892/or.4.4.775
MLA
Chen, H., Udelsman, R., Zeiger, M., Ball, D."Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors". Oncology Reports 4.4 (1997): 775-778.
Chicago
Chen, H., Udelsman, R., Zeiger, M., Ball, D."Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors". Oncology Reports 4, no. 4 (1997): 775-778. https://doi.org/10.3892/or.4.4.775