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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 1997 Volume 4 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1997 Volume 4 Issue 5

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Article

Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity

  • Authors:
    • J Sastre
    • E DiazRubio
    • L Cifuentes
    • J Blanco

  • View Affiliations / Copyright

    Affiliations: HU SAN CARLOS,MED ONCOL SERV,DEPT PATHOL,MADRID 28040,SPAIN.
  • Pages: 1089-1091
    |
    Published online on: September 1, 1997
       https://doi.org/10.3892/or.4.5.1089
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Abstract

Glutathione (GSH) is an intracellular thiol compound which has been shown to protect against cisplatin-induced nephrotoxicity, in animal models and clinical trials. In order to determine whether GSH interferes with cisplatin activity, the lymphoma L5178Y was implanted in 50 DBA/2 mice, and then they were treated with cisplatin with or without previous GSH. Two similar experiments were carried out with three different groups: Group 1: Control group without cisplatin; Group 2: Treatment with cisplatin without GSH, and Group 3: GSH administration prior to cisplatin. Tumor area and survival have been considered as parameters to measure the activity of cisplatin. The average Values of tumor areas in the mice pretreated with GSH were not significantly different from those corresponding to the group treated with cisplatin alone. Sixty days survival was 55% and 73% in the groups pretreated with GSH and with cisplatin alone respectively, the difference was not statistically significant. In conclusion, GSH administration prior to cisplatin does not modify its cytotoxic activity.

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Copy and paste a formatted citation
Spandidos Publications style
Sastre J, DiazRubio E, Cifuentes L and Blanco J: Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity. Oncol Rep 4: 1089-1091, 1997.
APA
Sastre, J., DiazRubio, E., Cifuentes, L., & Blanco, J. (1997). Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity. Oncology Reports, 4, 1089-1091. https://doi.org/10.3892/or.4.5.1089
MLA
Sastre, J., DiazRubio, E., Cifuentes, L., Blanco, J."Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity". Oncology Reports 4.5 (1997): 1089-1091.
Chicago
Sastre, J., DiazRubio, E., Cifuentes, L., Blanco, J."Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity". Oncology Reports 4, no. 5 (1997): 1089-1091. https://doi.org/10.3892/or.4.5.1089
Copy and paste a formatted citation
x
Spandidos Publications style
Sastre J, DiazRubio E, Cifuentes L and Blanco J: Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity. Oncol Rep 4: 1089-1091, 1997.
APA
Sastre, J., DiazRubio, E., Cifuentes, L., & Blanco, J. (1997). Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity. Oncology Reports, 4, 1089-1091. https://doi.org/10.3892/or.4.5.1089
MLA
Sastre, J., DiazRubio, E., Cifuentes, L., Blanco, J."Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity". Oncology Reports 4.5 (1997): 1089-1091.
Chicago
Sastre, J., DiazRubio, E., Cifuentes, L., Blanco, J."Glutathione administration against cisplatin-induced nephrotoxicity does not modify its cytotoxic activity". Oncology Reports 4, no. 5 (1997): 1089-1091. https://doi.org/10.3892/or.4.5.1089
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