Expression of thymidine phosphorylase and angiogenesis in human ovarian tumor

  • Authors:
    • K Iemura
    • Y Takebayashi
    • K Miyadera
    • Y Yamada
    • S Akiyama
    • Y Nagata
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/or.4.6.1181
  • Pages: 1181-1185
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Abstract

Thymidine phosphorylase (dThdPase) is an enzyme involved in pyrimidine nucleoside metabolism. dThdPase activity is increased in various types of malignant tumors. Recently, we demonstrated that dThdPase is identical to platelet-derived endothelial cell growth factor (PD-ECGF), and has angiogenic activity. We measured the dThdPase activity and the level of thrombomodulin (TM), as a marker for endothelial cells, in ovarian carcinomas, benign tumors and normal ovarian tissues. The average dThdPase activity of ovarian carcinomas (10.86+/-6.98 nmol/100 mu g protein/h) was significantly higher than that of benign tumors (4.66+/-3.91 nmol/100 mu g protein/h) or normal tissues (2.52+/-1.90 nmol/100 mu g protein/h). The expression of dThdPase detected by immunoblot analysis was well correlated with dThdPase activity. In an immunohistochemical study, the expression of dThdPase was more frequently observed in ovarian carcinomas than in benign tumors or normal tissues. dThdPase activity in human ovarian carcinomas was significantly correlated with the expression of TM in human ovarian carcinomas. These findings suggest that dThdPase expression is significantly correlated with angiogenesis in ovarian tumors.

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November 1997
Volume 4 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Iemura K, Takebayashi Y, Miyadera K, Yamada Y, Akiyama S and Nagata Y: Expression of thymidine phosphorylase and angiogenesis in human ovarian tumor. Oncol Rep 4: 1181-1185, 1997
APA
Iemura, K., Takebayashi, Y., Miyadera, K., Yamada, Y., Akiyama, S., & Nagata, Y. (1997). Expression of thymidine phosphorylase and angiogenesis in human ovarian tumor. Oncology Reports, 4, 1181-1185. https://doi.org/10.3892/or.4.6.1181
MLA
Iemura, K., Takebayashi, Y., Miyadera, K., Yamada, Y., Akiyama, S., Nagata, Y."Expression of thymidine phosphorylase and angiogenesis in human ovarian tumor". Oncology Reports 4.6 (1997): 1181-1185.
Chicago
Iemura, K., Takebayashi, Y., Miyadera, K., Yamada, Y., Akiyama, S., Nagata, Y."Expression of thymidine phosphorylase and angiogenesis in human ovarian tumor". Oncology Reports 4, no. 6 (1997): 1181-1185. https://doi.org/10.3892/or.4.6.1181