Alteration of polyunsaturated fatty acid pattern of plasma phospholipids and antioxidants in cervical HPV infection and neoplasia

  • Authors:
    • M Pozzi
    • B Villaccio
    • M Picardo
    • E Camera
    • A DiCarlo
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/or.4.6.1243
  • Pages: 1243-1247
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Abstract

The complex interactions between host immunity and infectious diseases have been documented in literature and they play a role in virus infection. Many clinical-experimental reports have stressed the importance of homeostasis of cell membranes and of the 'cell healthy indicators', namely polyunsaturated fatty acids and antioxidants in HIV infection. Today's increased incidence of heterosexual transmission of HIV has showed a strict correlation between HIV and HPV infection. According to some studies, positive HIV subjects have 40-200 times a greater risk of becoming HIV-positive. We have evaluated in 40 women with HIV infection the plasma levels of polyunsaturated fatty acids of phospholipids and vitamin E, determined by GC-MS methods, and the erythrocyte glutathione peroxidase activity (GHS-Px) by spectrophotometric techniques. The alteration of these parameters were correlated with the progression of the infection, i.e. the appearance of dysplastic or neoplastic pathologies on the uterine cervix. The differences were statistically significant (p<0.001) in subjects with cervical cancer with respect to both normal controls and patients with condylomatosis.

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November 1997
Volume 4 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Pozzi M, Villaccio B, Picardo M, Camera E and DiCarlo A: Alteration of polyunsaturated fatty acid pattern of plasma phospholipids and antioxidants in cervical HPV infection and neoplasia. Oncol Rep 4: 1243-1247, 1997
APA
Pozzi, M., Villaccio, B., Picardo, M., Camera, E., & DiCarlo, A. (1997). Alteration of polyunsaturated fatty acid pattern of plasma phospholipids and antioxidants in cervical HPV infection and neoplasia. Oncology Reports, 4, 1243-1247. https://doi.org/10.3892/or.4.6.1243
MLA
Pozzi, M., Villaccio, B., Picardo, M., Camera, E., DiCarlo, A."Alteration of polyunsaturated fatty acid pattern of plasma phospholipids and antioxidants in cervical HPV infection and neoplasia". Oncology Reports 4.6 (1997): 1243-1247.
Chicago
Pozzi, M., Villaccio, B., Picardo, M., Camera, E., DiCarlo, A."Alteration of polyunsaturated fatty acid pattern of plasma phospholipids and antioxidants in cervical HPV infection and neoplasia". Oncology Reports 4, no. 6 (1997): 1243-1247. https://doi.org/10.3892/or.4.6.1243