Elevation in putrescine level and spermidine/spermine N1-acetyltransferase activity coincide with tumor development in 1, 2-dimethylhydrazine-induced rat colon.

  • Authors:
    • A Shigesawa
    • N Onoda
    • Y S Chung
    • Y Yano
    • S Otani
    • S Fukushima
    • M Sowa
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/or.5.1.125
  • Pages: 125-134
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Spermidine/spermine N1-acetyltransferase (SSAT), rate-limiting enzyme of polyamine interconversion, has been demonstrated to play an important role in malignant transformation of cells. We examined the involvement of altered polyamine metabolism in the colonic carcinogenesis, using 1,2-dimethylhydrazine (DMH)-induced rat colon tumor model. Following findings were obtained: i) Ornithine decarboxylase demonstrated high activity from the early phase in colon mucosa, and increased significantly in tumors. ii) Spermidine and spermine levels gradually elevated in DMH-treated mucosa, while putrescine increased significantly in tumor tissues. iii) SSAT activity increased gradually in DMH-treated colon mucosa, which preceded elevation of tissue putrescine level, and coincided with tumor development. In conclusion, elevation of putrescine level and induction of SSAT activity are suggested to have a close association in colonic carcinogenesis.

Related Articles

Journal Cover

Jan-Feb 1998
Volume 5 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shigesawa A, Onoda N, Chung Y, Yano Y, Otani S, Fukushima S and Sowa M: Elevation in putrescine level and spermidine/spermine N1-acetyltransferase activity coincide with tumor development in 1, 2-dimethylhydrazine-induced rat colon.. Oncol Rep 5: 125-134, 1998.
APA
Shigesawa, A., Onoda, N., Chung, Y., Yano, Y., Otani, S., Fukushima, S., & Sowa, M. (1998). Elevation in putrescine level and spermidine/spermine N1-acetyltransferase activity coincide with tumor development in 1, 2-dimethylhydrazine-induced rat colon.. Oncology Reports, 5, 125-134. https://doi.org/10.3892/or.5.1.125
MLA
Shigesawa, A., Onoda, N., Chung, Y., Yano, Y., Otani, S., Fukushima, S., Sowa, M."Elevation in putrescine level and spermidine/spermine N1-acetyltransferase activity coincide with tumor development in 1, 2-dimethylhydrazine-induced rat colon.". Oncology Reports 5.1 (1998): 125-134.
Chicago
Shigesawa, A., Onoda, N., Chung, Y., Yano, Y., Otani, S., Fukushima, S., Sowa, M."Elevation in putrescine level and spermidine/spermine N1-acetyltransferase activity coincide with tumor development in 1, 2-dimethylhydrazine-induced rat colon.". Oncology Reports 5, no. 1 (1998): 125-134. https://doi.org/10.3892/or.5.1.125