Apoptosis induction in fludarabine resistant malignant B-1 cells by G2-M cell cycle arrest.

  • Authors:
    • M Zhang
    • E S Raveche
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/or.5.1.23
  • Pages: 23-53
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Abstract

A malignant B-1 cell line from a mouse model of CLL was resistant to fludarabine, but could be induced to undergo apoptosis by mitotic spindle inhibitors, colcemid or nocodazole, which blocked these cells in the G2-M phases of cell cycle prior to apoptosis induction. Bax mRNA levels increased with relative constitutive expression of bcl-2 mRNA levels. The mRNA levels of B-cell-specific-activator-protein (BSAP) decreased with colcemid treatment. This study shows that mitotic spindle inhibitors can induce apoptosis in fludarabine-resistant malignant B-1 cells by altering levels of bax/ bcl-2 ratio and BSAP which play different roles in cell cycle regulation and apoptosis induction.

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Jan-Feb 1998
Volume 5 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang M and Zhang M: Apoptosis induction in fludarabine resistant malignant B-1 cells by G2-M cell cycle arrest.. Oncol Rep 5: 23-53, 1998
APA
Zhang, M., & Zhang, M. (1998). Apoptosis induction in fludarabine resistant malignant B-1 cells by G2-M cell cycle arrest.. Oncology Reports, 5, 23-53. https://doi.org/10.3892/or.5.1.23
MLA
Zhang, M., Raveche, E."Apoptosis induction in fludarabine resistant malignant B-1 cells by G2-M cell cycle arrest.". Oncology Reports 5.1 (1998): 23-53.
Chicago
Zhang, M., Raveche, E."Apoptosis induction in fludarabine resistant malignant B-1 cells by G2-M cell cycle arrest.". Oncology Reports 5, no. 1 (1998): 23-53. https://doi.org/10.3892/or.5.1.23