Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors.

  • Authors:
    • C Hizel
    • M Ferrara
    • H Cure
    • D Pezet
    • P Dechelotte
    • J Chipponi
    • P Rio
    • Y J Bignon
    • D Bernard-Gallon
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/or.5.1.31
  • Pages: 31-35
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Abstract

To evaluate the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors, we have determined the ratio of the spliced form for the exon 2/the complete form of cathepsin B mRNAs obtained by RT-PCR. Such ratio is significantly higher in colorectal tumors than in colorectal mucosa (p < 0.05, Kruskal-Wallis test) or in skeletal muscle (p < 0.05). Moreover, 2-fold more complete form than the spliced mRNA was found in the tumors than in the colorectal mucosa. Our data indicate that the alternative splicing of human cathepsin B mRNA in the 5'UTR may be considered as an indicator of the cellular transformation, in colorectal cancer.

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Jan-Feb 1998
Volume 5 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hizel C, Ferrara M, Cure H, Pezet D, Dechelotte P, Chipponi J, Rio P, Bignon Y and Bernard-Gallon D: Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors.. Oncol Rep 5: 31-35, 1998
APA
Hizel, C., Ferrara, M., Cure, H., Pezet, D., Dechelotte, P., Chipponi, J. ... Bernard-Gallon, D. (1998). Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors.. Oncology Reports, 5, 31-35. https://doi.org/10.3892/or.5.1.31
MLA
Hizel, C., Ferrara, M., Cure, H., Pezet, D., Dechelotte, P., Chipponi, J., Rio, P., Bignon, Y., Bernard-Gallon, D."Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors.". Oncology Reports 5.1 (1998): 31-35.
Chicago
Hizel, C., Ferrara, M., Cure, H., Pezet, D., Dechelotte, P., Chipponi, J., Rio, P., Bignon, Y., Bernard-Gallon, D."Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors.". Oncology Reports 5, no. 1 (1998): 31-35. https://doi.org/10.3892/or.5.1.31