Cytotoxic agents active against mucinous adenocarcinoma of the ovary.

  • Authors:
    • Y Shimizu
    • H Nagata
    • Y Kikuchi
    • S Umezawa
    • K Hasumi
    • T Yokokura
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/or.5.1.99
  • Pages: 99-200
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Abstract

The purpose of the present study was to evaluate cytotoxic agents active for mucinous adenocarcinoma of the ovary (MACO) which is considered to be intrinsically platinum-resistant. We first conducted in vitro chemosensitivity tests assessing cytotoxic activities of various anti-cancer agents against MACO using a cell line, designated OMC-3, established from ascites of a patient with histologically pure MACO. The most active single agent was SN-38 (active substance of CPT-11 in vivo). The second most potent agent was mitomycin-C (MMC) followed by doxorubicin (DOX). In vivo chemo-sensitivity test of agents on OMC-3 transplanted into Balb/c nude mice demonstrated that MMC was most potent, followed by DOX. Moreover, a combination of CPT-11 and MMC exhibited the highest anti-tumor activity in this animal model. Cisplatin was found to be ineffective in both the in vitro and in vivo experimental system. Clinical trial with a combination of MMC and CPT-11 are justified in patients with MACO.

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Jan-Feb 1998
Volume 5 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Shimizu Y, Nagata H, Kikuchi Y, Umezawa S, Hasumi K and Yokokura T: Cytotoxic agents active against mucinous adenocarcinoma of the ovary.. Oncol Rep 5: 99-200, 1998.
APA
Shimizu, Y., Nagata, H., Kikuchi, Y., Umezawa, S., Hasumi, K., & Yokokura, T. (1998). Cytotoxic agents active against mucinous adenocarcinoma of the ovary.. Oncology Reports, 5, 99-200. https://doi.org/10.3892/or.5.1.99
MLA
Shimizu, Y., Nagata, H., Kikuchi, Y., Umezawa, S., Hasumi, K., Yokokura, T."Cytotoxic agents active against mucinous adenocarcinoma of the ovary.". Oncology Reports 5.1 (1998): 99-200.
Chicago
Shimizu, Y., Nagata, H., Kikuchi, Y., Umezawa, S., Hasumi, K., Yokokura, T."Cytotoxic agents active against mucinous adenocarcinoma of the ovary.". Oncology Reports 5, no. 1 (1998): 99-200. https://doi.org/10.3892/or.5.1.99