Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.

  • Authors:
    • I Sekine
    • S Takami
    • S G Guang
    • T Yokose
    • T Kodama
    • Y Nishiwaki
    • M Kinoshita
    • H Matsumoto
    • T Ogura
    • K Nagai
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/or.5.2.351
  • Pages: 351-355
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Abstract

Overexpression of epidermal growth factor receptor (EGF-R), K-ras gene mutations and c-myc gene amplification were studied in tumor and normal lung tissues from 100 patients with non-small cell lung cancer. The mean a standard deviation (SD) of the amount of EGF-R in the tumor (N=97) and the normal (N=82) tissues were 16.0 +/- 3.7 and 10.8 +/- 2.0 fmol/mg, respectively (P=0.015). Overexpression of the receptor was observed in 6 (24.0%) of 25 squamous cell carcinomas, 16 (23.2%) of 69 adenocarcinomas and 23 (23.7%) of a total of 97 tumors. K-ras mutations were observed in nine (9%) of 100 tumors. Of these, five (55.6%) mutations were in codon 12, one (11.1%) was in codon 22, and three (33.3%) were in codon 61. The patterns of the mutations were GC transversions in three (33.3%) tumors, GC transitions in two ( 22.2%) and AT transversions in four (44.4%) tumors. There was no association between EGF-R overexpression and K-ras mutation. c-myc amplification was studied in 23, but was not detected in any tumor (mean number of copies +/- SD = 1.28 +/- 0.24).

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Mar-Apr 1998
Volume 5 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sekine I, Takami S, Guang S, Yokose T, Kodama T, Nishiwaki Y, Kinoshita M, Matsumoto H, Ogura T, Nagai K, Nagai K, et al: Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.. Oncol Rep 5: 351-355, 1998
APA
Sekine, I., Takami, S., Guang, S., Yokose, T., Kodama, T., Nishiwaki, Y. ... Nagai, K. (1998). Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.. Oncology Reports, 5, 351-355. https://doi.org/10.3892/or.5.2.351
MLA
Sekine, I., Takami, S., Guang, S., Yokose, T., Kodama, T., Nishiwaki, Y., Kinoshita, M., Matsumoto, H., Ogura, T., Nagai, K."Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.". Oncology Reports 5.2 (1998): 351-355.
Chicago
Sekine, I., Takami, S., Guang, S., Yokose, T., Kodama, T., Nishiwaki, Y., Kinoshita, M., Matsumoto, H., Ogura, T., Nagai, K."Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.". Oncology Reports 5, no. 2 (1998): 351-355. https://doi.org/10.3892/or.5.2.351