A human lung cancer xenograft producing granulocyte-colony stimulating factor and parathyroid hormone-related protein.

  • Authors:
    • Y Oshika
    • M Nakamura
    • H Hatanaka
    • Y Abe
    • T Tokunaga
    • Y Ohnishi
    • H Kijima
    • H Yamazaki
    • N Tamaoki
    • Y Ueyama
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/or.5.2.359
  • Pages: 359-421
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Abstract

A human lung cancer xenograft, LC-GP, producing granulocyte-colony stimulating factor and parathyroid hormone-related protein was established by transplantation into severe combined immunodeficient (SCID) mice. The lung cancer patient and SCID mice bearing LC-GP showed leukocytosis and hypercalcemia. G-CSF and PTHrP gene expression were demonstrated in the primary lung cancer, metastatic lesions and LC-GP xenograft. Immunohistochemical analysis confirmed the presence of G-CSF protein in LC-GP xenograft cells. LC-GP possessed activated c-Ki-ras oncogene (point mutation at codon 12). This LC-GP lacked apparent G-CSF receptor expression. The expression of G-CSF and PTHrP may be coregulated by the activated c-Ki-ras oncogene, and autocrine stimulation of G-CSF is unlikely.

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Mar-Apr 1998
Volume 5 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Oshika Y, Nakamura M, Hatanaka H, Abe Y, Tokunaga T, Ohnishi Y, Kijima H, Yamazaki H, Tamaoki N, Ueyama Y, Ueyama Y, et al: A human lung cancer xenograft producing granulocyte-colony stimulating factor and parathyroid hormone-related protein.. Oncol Rep 5: 359-421, 1998
APA
Oshika, Y., Nakamura, M., Hatanaka, H., Abe, Y., Tokunaga, T., Ohnishi, Y. ... Ueyama, Y. (1998). A human lung cancer xenograft producing granulocyte-colony stimulating factor and parathyroid hormone-related protein.. Oncology Reports, 5, 359-421. https://doi.org/10.3892/or.5.2.359
MLA
Oshika, Y., Nakamura, M., Hatanaka, H., Abe, Y., Tokunaga, T., Ohnishi, Y., Kijima, H., Yamazaki, H., Tamaoki, N., Ueyama, Y."A human lung cancer xenograft producing granulocyte-colony stimulating factor and parathyroid hormone-related protein.". Oncology Reports 5.2 (1998): 359-421.
Chicago
Oshika, Y., Nakamura, M., Hatanaka, H., Abe, Y., Tokunaga, T., Ohnishi, Y., Kijima, H., Yamazaki, H., Tamaoki, N., Ueyama, Y."A human lung cancer xenograft producing granulocyte-colony stimulating factor and parathyroid hormone-related protein.". Oncology Reports 5, no. 2 (1998): 359-421. https://doi.org/10.3892/or.5.2.359