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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Mar-Apr 1998 Volume 5 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar-Apr 1998 Volume 5 Issue 2

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Article

Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.

  • Authors:
    • E T Wong
    • S O'Brien

  • View Affiliations / Copyright

    Affiliations: Brain Tumor Center and Neuro-Oncology Unit, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
  • Pages: 493-498
    |
    Published online on: March 1, 1998
       https://doi.org/10.3892/or.5.2.493
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Abstract

Refractory anemia with excess blasts in transformation (RAEB-T) is a pre-leukemic syndrome that can progress to acute myelogenous leukemia (AML). Although leptomeningeal disease in AML is rare and it is commonly associated with specific cytogenetic abnormalities, it has not been documented in RAEB-T. We report a woman who experienced seizures and had subarachnoid enhancement on MRI suggestive of leukemic infiltrates in the leptomeninges. Her bone marrow aspirate revealed 6.6% blasts and the presence of Auer rods, findings consistent with a diagnosis of RAEB-T. Subsequent cytogenetic analysis detected an uncommon deletion of chromosome 11q23, and the breakpoint on chromosome 11 is identical to that seen in AML patients having leptomeningeal disease and translocation between chromosome 9 and 11. Although RAEB-T is not considered as leukemia and is thought unlikely to involve the central nervous system, the presence of leptomeningeal disease and 11q23 deletion in our patient suggests that cytogenetic abnormality may be an important determinant of neurological complications, regardless of a diagnosis of RAEB-T or AML which is based on cellular morphology.

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Copy and paste a formatted citation
Spandidos Publications style
Wong E and O'Brien S: Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.. Oncol Rep 5: 493-498, 1998.
APA
Wong, E., & O'Brien, S. (1998). Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.. Oncology Reports, 5, 493-498. https://doi.org/10.3892/or.5.2.493
MLA
Wong, E., O'Brien, S."Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.". Oncology Reports 5.2 (1998): 493-498.
Chicago
Wong, E., O'Brien, S."Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.". Oncology Reports 5, no. 2 (1998): 493-498. https://doi.org/10.3892/or.5.2.493
Copy and paste a formatted citation
x
Spandidos Publications style
Wong E and O'Brien S: Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.. Oncol Rep 5: 493-498, 1998.
APA
Wong, E., & O'Brien, S. (1998). Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.. Oncology Reports, 5, 493-498. https://doi.org/10.3892/or.5.2.493
MLA
Wong, E., O'Brien, S."Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.". Oncology Reports 5.2 (1998): 493-498.
Chicago
Wong, E., O'Brien, S."Leptomeningeal disease in pre-leukemic syndrome: cytogenetic abnormality versus cellular morphology.". Oncology Reports 5, no. 2 (1998): 493-498. https://doi.org/10.3892/or.5.2.493
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