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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May-Jun 1998 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-Jun 1998 Volume 5 Issue 3

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Article

BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.

  • Authors:
    • J Q Cui
    • N Shao
    • Y Chai
    • H Wang
    • E S Reddy
    • V N Rao

  • View Affiliations / Copyright

    Affiliations: Division of Cancer Genetics, Department of Human Genetics, Allegheny University of the Health Sciences, M.S. 481, New College Building, Broad and Vine Streets, Philadelphia, PA 19102, USA.
  • Pages: 591-596
    |
    Published online on: May 1, 1998
       https://doi.org/10.3892/or.5.3.591
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Abstract

The tumor suppressor gene BRCA1, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. CBP is a component of the holoenzyme. Previously, we have characterized two new BRCA1 splice variants BRCA1a/p110 and BRCA1b/p100. In the present study, the carboxy-terminal domain of transcription factor CBP interacts both in vivo and in vitro with full length BRCA1a and BRCA1b proteins as demonstrated by mammalian two- hybrid assays, co-immunoprecipitation/western blot studies, GST binding assays and histone acetyl transferase (HAT) assays of BRCA1 immunoprecipitates from human breast cancer cells. Our results suggest that one of the mechanisms by which BRCA1 proteins function is through recruitment of CBP associated HAT/FAT (transcription factor acetyl-transferase) activity for acetylation of either themselves or general transcription factors or both to specific promoters resulting in transcriptional activation.

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Copy and paste a formatted citation
Spandidos Publications style
Cui J, Shao N, Chai Y, Wang H, Reddy E and Rao V: BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.. Oncol Rep 5: 591-596, 1998.
APA
Cui, J., Shao, N., Chai, Y., Wang, H., Reddy, E., & Rao, V. (1998). BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.. Oncology Reports, 5, 591-596. https://doi.org/10.3892/or.5.3.591
MLA
Cui, J., Shao, N., Chai, Y., Wang, H., Reddy, E., Rao, V."BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.". Oncology Reports 5.3 (1998): 591-596.
Chicago
Cui, J., Shao, N., Chai, Y., Wang, H., Reddy, E., Rao, V."BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.". Oncology Reports 5, no. 3 (1998): 591-596. https://doi.org/10.3892/or.5.3.591
Copy and paste a formatted citation
x
Spandidos Publications style
Cui J, Shao N, Chai Y, Wang H, Reddy E and Rao V: BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.. Oncol Rep 5: 591-596, 1998.
APA
Cui, J., Shao, N., Chai, Y., Wang, H., Reddy, E., & Rao, V. (1998). BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.. Oncology Reports, 5, 591-596. https://doi.org/10.3892/or.5.3.591
MLA
Cui, J., Shao, N., Chai, Y., Wang, H., Reddy, E., Rao, V."BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.". Oncology Reports 5.3 (1998): 591-596.
Chicago
Cui, J., Shao, N., Chai, Y., Wang, H., Reddy, E., Rao, V."BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.". Oncology Reports 5, no. 3 (1998): 591-596. https://doi.org/10.3892/or.5.3.591
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