TNF, IL-1 and IL-6 in circulating blood after total-body and localized irradiation in rats.

  • Authors:
    • J Haveman
    • A G Geerdink
    • H M Rodermond
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/or.5.3.679
  • Pages: 679-762
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Abstract

The levels of TNF, IL-1 and IL-6 in circulating blood of female WAG/Rij rats were assessed both after total-body irradiation (TBI) and localized irradiation of the right hind leg. The results show that enhanced levels of IL-1 in the circulation reflect a stress situation presumably resulting from handling and halothane anesthesia of the animal. Neither localized irradiation nor TBI resulted in further enhanced levels of IL-1. Both TBI and localized irradiation, lead to a small but significant increase in IL-6 levels in serum from circulating blood. After TBI this increase dissipated rapidly, 24 h after TBI increased levels are not found. After localized irradiation IL-6 levels remain elevated for a longer period. Still two weeks after irradiation, the longest time investigated, increased levels were observed. We did not observe increased TNF levels after localized irradiation or after TBI.

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May-Jun 1998
Volume 5 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Haveman J, Geerdink A and Rodermond H: TNF, IL-1 and IL-6 in circulating blood after total-body and localized irradiation in rats.. Oncol Rep 5: 679-762, 1998
APA
Haveman, J., Geerdink, A., & Rodermond, H. (1998). TNF, IL-1 and IL-6 in circulating blood after total-body and localized irradiation in rats.. Oncology Reports, 5, 679-762. https://doi.org/10.3892/or.5.3.679
MLA
Haveman, J., Geerdink, A., Rodermond, H."TNF, IL-1 and IL-6 in circulating blood after total-body and localized irradiation in rats.". Oncology Reports 5.3 (1998): 679-762.
Chicago
Haveman, J., Geerdink, A., Rodermond, H."TNF, IL-1 and IL-6 in circulating blood after total-body and localized irradiation in rats.". Oncology Reports 5, no. 3 (1998): 679-762. https://doi.org/10.3892/or.5.3.679