Effects of azoxymethane on X-ray induced intestinal metaplasia in Donryu rats.

Watanabe,H; Fujimoto,N; Masaoka,Y; Kurosumi,M; Oguri,T; Takahashi,T; Kido,S; Hirata,S; Kuramoto,K; Shoji,S; Katoh,O

doi:10.3892/or.5.4.837

Effects of azoxymethane on X-ray induced intestinal metaplasia in Donryu rats.

Authors:
- H Watanabe
- N Fujimoto
- Y Masaoka
- M Kurosumi
- T Oguri
- T Takahashi
- S Kido
- S Hirata
- K Kuramoto
- S Shoji
- O Katoh
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Affiliations: Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima, 734-8553, Japan.
Published online on: July 1, 1998 https://doi.org/10.3892/or.5.4.837
Pages: 837-877

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Abstract

The present study was undertaken to determine the effect of azoxymethane (AOM) administration on intestinal metaplasia induced by X-irradiation in male Donryu rats. Five-week-old animals were X-irradiated with two doses of 10 Gy each at a 3-day interval or three X-ray doses of 10 Gy at a 2-day interval and then received AOM injections i.m. at a dose of 15 mg/kg body weight once weekly for 3 weeks, 6 months after irradiation. Alkaline phosphatase positive foci were decreased after AOM treatments, but aberrant crypt like-foci appeared within areas of intestinal metaplasia. In contrast no induction was observed in normal-appearing gastric mucosa.