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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 1998 Volume 5 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
Jul-Aug 1998 Volume 5 Issue 4

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Article

Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.

  • Authors:
    • P Gazzaniga
    • A Gradilone
    • I Silvestri
    • O Gandini
    • L Giuliani
    • A Vincenzoni
    • M Gallucci
    • L Frati
    • A M Agliano

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Medicina Sperimentale e Patologia, Universita degli Studi di Roma, 00161 Roma, Italy.
  • Pages: 901-905
    |
    Published online on: July 1, 1998
       https://doi.org/10.3892/or.5.4.901
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Abstract

We investigated the expression of the anti-apoptotic genes bcl-2 and bcl-X and the pro-apoptotic gene bax in bladder tumors and normal samples from urinary bladder, using RT-PCR analysis. Bcl-2 mRNA was not detected in any of the normal samples, while it was found expressed in 66% of the low stage tumors and in 100% of the high stage tumors. Bax expression had an inverse progress, being present in 62% of the normal tissues examined, in 16% of the low stage tumors and in 14% of the high stage. Bcl-X gene expression was quite variable among all samples (37% in normal tissues, 50% in the low stage tumors and 14% in the high stage). bcl-X mRNA was only found in the isoform bcl-XL, with anti-apoptotic functions, whereas no sample expressed the isoform bcl-XS, which is known to suppress bcl-2 functions. Most samples expressing bcl-2 did not express bcl-X, and vice versa. These results, besides confirming the potential role of these genes in the pathogenesis of low stage bladder cancer strengthen the hypothesis concerning their possible interaction in the progression of disease.

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Copy and paste a formatted citation
Spandidos Publications style
Gazzaniga P, Gradilone A, Silvestri I, Gandini O, Giuliani L, Vincenzoni A, Gallucci M, Frati L and Agliano A: Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.. Oncol Rep 5: 901-905, 1998.
APA
Gazzaniga, P., Gradilone, A., Silvestri, I., Gandini, O., Giuliani, L., Vincenzoni, A. ... Agliano, A. (1998). Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.. Oncology Reports, 5, 901-905. https://doi.org/10.3892/or.5.4.901
MLA
Gazzaniga, P., Gradilone, A., Silvestri, I., Gandini, O., Giuliani, L., Vincenzoni, A., Gallucci, M., Frati, L., Agliano, A."Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.". Oncology Reports 5.4 (1998): 901-905.
Chicago
Gazzaniga, P., Gradilone, A., Silvestri, I., Gandini, O., Giuliani, L., Vincenzoni, A., Gallucci, M., Frati, L., Agliano, A."Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.". Oncology Reports 5, no. 4 (1998): 901-905. https://doi.org/10.3892/or.5.4.901
Copy and paste a formatted citation
x
Spandidos Publications style
Gazzaniga P, Gradilone A, Silvestri I, Gandini O, Giuliani L, Vincenzoni A, Gallucci M, Frati L and Agliano A: Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.. Oncol Rep 5: 901-905, 1998.
APA
Gazzaniga, P., Gradilone, A., Silvestri, I., Gandini, O., Giuliani, L., Vincenzoni, A. ... Agliano, A. (1998). Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.. Oncology Reports, 5, 901-905. https://doi.org/10.3892/or.5.4.901
MLA
Gazzaniga, P., Gradilone, A., Silvestri, I., Gandini, O., Giuliani, L., Vincenzoni, A., Gallucci, M., Frati, L., Agliano, A."Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.". Oncology Reports 5.4 (1998): 901-905.
Chicago
Gazzaniga, P., Gradilone, A., Silvestri, I., Gandini, O., Giuliani, L., Vincenzoni, A., Gallucci, M., Frati, L., Agliano, A."Variable levels of bcl-2, bcl-x and bax mRNA in bladder cancer progression.". Oncology Reports 5, no. 4 (1998): 901-905. https://doi.org/10.3892/or.5.4.901
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