Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation.

  • Authors:
    • S Shoji
    • Y Masaoka
    • M Kurosumi
    • O Katoh
    • H Watanabe
  • View Affiliations

  • Published online on: September 1, 1998     https://doi.org/10.3892/or.5.5.1175
  • Pages: 1175-1183
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Experiments were conducted to determine whether following genetic damage at germ cell stages induced by paternal exposure to 252Cf fission neutron could lead to tumorigenesis in the offspring. Seven-week-old C3H/HeNCrj male mice were irradiated with 252Cf fission neutrons, at doses of 0 and 12.5 cGy and were mated with nine-week-old C57BL/6NCrj females two weeks after the exposure. Three weeks later, it was found that the proportion of abnormal sperm in the 12.5 cGy-irradiated males was higher than that of 0 cGy-irradiated group. Embryo lethality among the F1 offspring was also found to be higher in the 12.5 cGy group than in the 0 cGy group, while the incidence of liver tumors among the F1 offspring increased in males only. These results suggest that the paternal 12. 5 cGy radiation exposure may have caused genetic transmission of liver tumor-associated traits, which is in line with findings that show steep increase in incidence of tumorigenesis in B6C3F1.

Related Articles

Journal Cover

Sep-Oct 1998
Volume 5 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shoji S, Masaoka Y, Kurosumi M, Katoh O and Watanabe H: Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation.. Oncol Rep 5: 1175-1183, 1998
APA
Shoji, S., Masaoka, Y., Kurosumi, M., Katoh, O., & Watanabe, H. (1998). Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation.. Oncology Reports, 5, 1175-1183. https://doi.org/10.3892/or.5.5.1175
MLA
Shoji, S., Masaoka, Y., Kurosumi, M., Katoh, O., Watanabe, H."Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation.". Oncology Reports 5.5 (1998): 1175-1183.
Chicago
Shoji, S., Masaoka, Y., Kurosumi, M., Katoh, O., Watanabe, H."Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation.". Oncology Reports 5, no. 5 (1998): 1175-1183. https://doi.org/10.3892/or.5.5.1175