Induction of ovarian tumors by heavy ion irradiation in B6C3F1 mice.

Watanabe,H; Ogiu,T; Nishizaki,M; Fujimoto,N; Kido,S; Ishimura,Y; Shiraki,K; Kuramoto,K; Hirata,S; Shoji,S; Katoh,O

doi:10.3892/or.5.6.1377

Induction of ovarian tumors by heavy ion irradiation in B6C3F1 mice.

Authors:
- H Watanabe
- T Ogiu
- M Nishizaki
- N Fujimoto
- S Kido
- Y Ishimura
- K Shiraki
- K Kuramoto
- S Hirata
- S Shoji
- O Katoh
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Affiliations: Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan.
Published online on: November 1, 1998 https://doi.org/10.3892/or.5.6.1377
Pages: 1377-1457

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Abstract

Six-week-old B6C3F1 mice were exposed to 0.439 Gy heavy ion irradiation as a 290 MeV/u carbon-ion beam (LET 10 keV/micron) at 2 cm from the upper proximal point of a spread Bragg beam and autopsied 13.5 months after the irradiation. In males total tumor incidences, mainly liver tumors, were 37.0% in irradiated group and 25.0% in control (P>0.05). In females the total tumor incidences were 32.3%, mainly ovarian tumors, in the irradiated group and 0% in the controls. These results indicate that heavy ion irradiation induces ovarian tumors in females but does not target any organ in males.