Control of human vascular smooth muscle cell proliferation by sera derived from 'experimentally stressed' individuals.

  • Authors:
    • Y Cui
    • W H Gutstein
    • S Jabr
    • T C Hsieh
    • J M Wu
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/or.5.6.1471
  • Pages: 1471-1475
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Recently we reported that individuals with high scores in standardized hostility evaluation tests, when placed in a environment, may have an association with increases in a blood-borne mitogenic substance(s) for arterial smooth muscle cells. To further investigate the molecular basis for such an association, PDS [plasma derived serum with platelet derived growth factor (PDGF) removed] from individuals showing the greatest differential pre/post-stress mitogenic activity, were tested for ability to modulate changes in the steady state of the c-myc mRNA in cultured VSMC (vascular smooth muscle cells) by Northern blot analysis. Post-stress PDS resulted in a significant increase in c-myc mRNA, when compared with pre-stress PDS of the same individual. These results give further experimental support for the notion that stress (even in the form of transient, episodic psychological challenges) may affect the cardiovascular system via rapid elicited rises in serum mitogenic activity for VSMC.

Related Articles

Journal Cover

Nov-Dec 1998
Volume 5 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cui Y, Gutstein W, Jabr S, Hsieh T and Wu J: Control of human vascular smooth muscle cell proliferation by sera derived from 'experimentally stressed' individuals.. Oncol Rep 5: 1471-1475, 1998
APA
Cui, Y., Gutstein, W., Jabr, S., Hsieh, T., & Wu, J. (1998). Control of human vascular smooth muscle cell proliferation by sera derived from 'experimentally stressed' individuals.. Oncology Reports, 5, 1471-1475. https://doi.org/10.3892/or.5.6.1471
MLA
Cui, Y., Gutstein, W., Jabr, S., Hsieh, T., Wu, J."Control of human vascular smooth muscle cell proliferation by sera derived from 'experimentally stressed' individuals.". Oncology Reports 5.6 (1998): 1471-1475.
Chicago
Cui, Y., Gutstein, W., Jabr, S., Hsieh, T., Wu, J."Control of human vascular smooth muscle cell proliferation by sera derived from 'experimentally stressed' individuals.". Oncology Reports 5, no. 6 (1998): 1471-1475. https://doi.org/10.3892/or.5.6.1471