Cytokines in human breast cancer: IL-1alpha and IL-1beta expression.

Kurtzman,S H; Anderson,K H; Wang,Y; Miller,L J; Renna,M; Stankus,M; Lindquist,R R; Barrows,G; Kreutzer,D L

doi:10.3892/or.6.1.65

Cytokines in human breast cancer: IL-1alpha and IL-1beta expression.

Authors:
- S H Kurtzman
- K H Anderson
- Y Wang
- L J Miller
- M Renna
- M Stankus
- R R Lindquist
- G Barrows
- D L Kreutzer
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Affiliations: Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030-3105, USA.
Published online on: January 1, 1999 https://doi.org/10.3892/or.6.1.65
Pages: 65-135

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Abstract

We hypothesize that interleukin 1alpha (IL-1alpha) and interleukin 1beta (IL-1beta) are present and tumor cell associated in human breast cancer (HBC) specimens. To test our hypothesis: a) immunologic analysis was performed on HBC histologic sections for IL-1alpha (n=49) and IL-1beta (n=42) distribution; and b) homogenates of HBC tumors were analyzed for levels of IL-1alpha (n=82), IL-1beta (n=101) and interleukin 8 (IL-8) (n=103) expression. Immunohistochemical analysis demonstrated the presence of IL-1alpha and IL-1beta in tumor cells in patients with invasive cancer and ductal carcinoma in situ. Quantitative analysis confirmed the presence and positive correlation of IL-1alpha and IL-1beta to IL-8, a known angiogenic factor, in cancer specimens. These studies demonstrate that tumor-associated IL-1alpha+, IL-1beta are present in the tumor microenvironment and may play a pivotal role in regulating breast tumor growth and metastasis.