Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer.
- R E Harris
- S Kasbari
- W B Farrar
Affiliations: The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
- Published online on: January 1, 1999 https://doi.org/10.3892/or.6.1.71
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We conducted a prospective cohort study of Nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer among 32,505 women in central Ohio, USA. After 5 years of follow-up, a total of 393 cases have been detected. The annual incidence of breast cancer per 100,00 women varied inversely with increasing intake of NSAIDs, declining from 323 among non-users to 183 among heavy users (p<0.01). Breast cancer rates decreased by about 50% with regular ibuprofen intake (p<0.01), and by about 40% with regular aspirin intake (p<0.05). The results suggest that specific NSAIDs may be effective chemopreventive agents against breast cancer.